This study critically examined the effectiveness of English medium instruction (EMI) policy within the context of Korean higher education, putting a special focus on its implementation strategy. The data for this study were mainly drawn from student opinion surveys and focus group interviews conducted by the CTL (Center for Teaching and Learning) at KU. The research teams also carried out supplementary interviews with both professors and students. The results indicate that, although the EMI policy seems to have produced, in general, positive outcomes (i.e., with the overall satisfaction level with EMI or its overall effectiveness in improving students' English proficiency), the compulsory enforcement of EMI without regard to students'/instructors' language proficiency, the lack of a much-needed support system and appropriate instructors to conduct EMI classes, and the unilateral implementation of EMI across academic disciplines have brought about a number of side effects. Based on these findings, the study recommends for future EMI policy implementation (1) a more flexible approach, considering students' language proficiency and career plans and the characteristics of various academic disciplines and (2) more thorough preparation to implement the EMI policy (i.e., examination of the human and financial resources available for the institution concerned).

The highly oxygenated antifungal anticancer natural product (+/-)-diepoxin sigma was prepared in 10 steps and in 15% overall yield from O-methylnaphthazarin. Highlights of the synthetic work include an Ullmann coupling and a possibly biomimetic oxidative spirocyclization for the introduction of the naphthalene ketal as well as the use of a retro-Diels-Alder reaction to unmask the reactive enone moiety in the naphthoquinone bisepoxide ring system. A novel highly bulky chiral binaphthol ligand was developed for a boron-mediated Diels-Alder reaction that constitutes a formal asymmetric total synthesis of (+)-diepoxin sigma.

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The discovery and profiling of 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (5a, MK-0354), a partial agonist of GPR109a, is described. Compound 5a retained the plasma free fatty acid lowering effects in mice associated with GPR109a agonism, but did not induce vasodilation at the maximum feasible dose. Moreover, preadministration of 5a blocked the flushing effect induced by nicotinic acid but not that induced by PGD2. This profile made 5a a suitable candidate for further study for the treatment of dyslipidemia.

For anionic ROP, 1 must be extremely pure and is typically subjected to multiple (about four) sublimations and recrystallizations. and rigorously dry and anerobic reaction conditions must be used [lo]. COMMUNICATIONSA n~r i r Chcm Inr. €11 .En,?/. 1997. 36. No. 7 f> VCH ~r/ag.~gese/lschufi mhH. 0-69451 Weinheim, 1997 0570-0833!97/3607-0767 S 17.50+ .50 0