A case of systemic sclerosis associated with haemolytic anaemia from auto-antibodies is reported. The significance of this rare association, as indirect support for the possible auto-immune pathogenesis of scieroderma, is discussed. ANAEMIA in diffuse soleroderma has not received much attention, hut it i w not an infrequent finding. It was present in 6% of the 727 patients examined by Tuftanelli and VViTikeimann (1»61), and in 29% of the 164 cases studied by Westerman et al. (1!)G8). The causes of anaemia have been little iiivestigated, although it is known to he more frequent when there is systemic iiivolvt'inent and in tlie presence of complications such as renal iusufficiency, iron deficiency, poor intestinal absorption or haemolysis (Westerman et al., 1968). Haemolysis of an auto-immune nature, as in the following case report, has rarely been described.
CASE REPORTM.C., a wliite man aged 2fi, was admitted to the clinic on October 14th, 1967 having suffered for 2 years from progressive hardening of the skin. The lesions hegan on the forearms and increased gradually in severity and extent. About 9 months after the heginniiig of these symptoms, marked facial pallor «as observed, the patient was easily tirtKl and tliere was dyspnoea after effort of moderate intensity. No alteration in the colour of the urine and faeces was observed. Eighteen months later the patient began to suffer from trausitory vasomotor symptoms in his hands, which suddenly became white on exposure to cold, without acrocyanosis or pain. He liad not noted any bloo
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