To explore the effect of Ki-67 and vascular endothelial growth factor A (VEGF-A) expression on the risks of advanced T category (T3,4) and positive lymph node involvement (Nϩ) in oral and pharyngeal squamous cell carcinoma (SCC) compared with laryngeal SCC. Design: Immunohistochemical analysis of prospectively recruited patients. Setting: University-affiliated hospital. Patients: A total of 147 previously untreated patients with different stages of SCC in the oral cavity, pharynx, and larynx. Main Outcome Measures: Relative risks of T3,4 tumor and Nϩ, a risk ratio comparing risks under high vs low marker expression. Results: A significant association of Ki-67 and VEGF-A expression with tumor T category was observed for oral and pharyngeal SCC and for laryngeal SCC (PՅ.006). Regarding nodal status, Ki-67 expression was a significant risk factor for Nϩ in all tumors (PՅ.

No abstract

Café-au-lait macules are skin lesions known to resist all kinds of treatment. Green light at a wavelength of 511 nm from a copper vapour laser through a built-in computerized scanner (SCANALL) was employed to treat café-au-lait-macules in 16 patients. The laser was used in continuous mode with a mean energy density of 8.9 J/cm2 (range 7-22 J/cm2). The mean number of treatment sessions was two. The response was good to excellent in 15 cases and poor in one. Transient hyperpigmentation at the periphery and temporary non-homogeneous hypopigmentation at the centre of the treated area was observed in some cases. These eventually returned to normal after a few months, without any textural change. Pre- and postoperative histological finding are also presented. There was no recurrence at a mean follow-up time of 22 months. Copper vapour laser is an effective modality for the treatment of café-au-lait macules.

No abstract