Tom 74 • nr 3 • 2018 new nephrotoxic substances used during chemsex and co-morbidities influencing nephropathy in HIV positive individuals were analysed. Viral pathogens associated with kidney diseases such as CMV, EBV, VZV, adenoviruses and HBV or HCV were presented. Multiplicity and diversity of presented factors indicate how important is the problem of CKD in HIV positive patients. Awareness and analysis of these factors, systematic monitoring of the kidney function allows to adapt and modify therapy carried by clinicians.
Introduction: Human immunodeficiency virus (HIV) infection remains an important health problem despite the fact that combined antiretroviral therapy (cART) prolongs life and protects against acquired immunodeficiency syndrome (AIDS). Chronic kidney disease is an important cause of mortality among HIV patients, co-monitoring of renal function and modifying factors such as cART require constant analysis. The aim of this study was a retrospective analysis of renal function among HIVinfected and cART-treated patients by measuring urine concentrations of chosen low molecular weight proteins (LMWP) as biomarkers of kidney dysfunction: retinol-binding protein (RBP), β 2-microglobulin (β 2 M), and neutrophil gelatinase-associated lipocalin (NGAL). The results were compared with those obtained seven years earlier (in 2011) in the same patients. Material and methods: Urine samples from 34 patients of Wroclaw outpatient HIV Clinic and from 30 HIV-negative individuals with no renal or any other disease were examined. Concentrations of LMWP were measured by immunoenzymatic ELISA tests. Results: Compared to 2011, reduction in the concentration of excreted LMWP was observed. No deleterious renal effect of tenofovir could be shown; however, most patients were receiving the new prodrug (TAF) of reduced nephrotoxicity. Positive correlation between serum creatinine and urine β 2 M was shown and negative correlation between eGFR and urine RBP. Coexistence of HCV infection and the number of T CD4(+) cells also correlated with the concentration of the biomarkers. Conclusions: This retrospective analysis shows a need for long-term renal function monitoring as well as other factors that may influence renal function among HIV patients. RBP, NGAL, and β 2 M have been confirmed to be useful biomarkers for early detection of renal dysfunction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.