Justin R. Allen scite author profile

Justin R. Allen

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University of Southern California

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Covalent Small Ubiquitin-like Modifier (SUMO) Modification of Maf1 Protein Controls RNA Polymerase III-dependent Transcription Repression

Rohira

Chen

Allen

et al. 2013

Journal of Biological Chemistry

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Background: Maf1 is a central repressor of genes that promote oncogenesis, yet little is known about how Maf1 is regulated. Results: Maf1K35 SUMO modification is controlled by SENP1, affecting its ability to repress transcription and suppress cell growth. Conclusion: SUMOylation of Maf1 is implicated as a regulatory mechanism for RNA pol III transcription. Significance: A link between SENP1, Maf1, and RNA pol III-mediated transcription in oncogenesis is revealed.

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Justin R. Allen

Covalent Small Ubiquitin-like Modifier (SUMO) Modification of Maf1 Protein Controls RNA Polymerase III-dependent Transcription Repression

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