Studies of the effect of elevated levels of serum calcium on gastric secretion in dogs 1 7 indicate that there is no significant stimulation of acid secretion and that some degree of inhibition may occur.' In order to investigate the possible role of the gastrin mechanism in the stimulation of gastric secretion by infusion of calcium, we have studied the effects of the intravenous administration of calcium on gastric acid secretion and on the serum concentration of gastrin in duodenal ulcer patients and in normal individuals. We further tested the effect of calcium infusion on

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