Influence of Hypercalcemia on Gastric Secretion and Serum Gastrin Concentrations in Man

Reeder, David D.; Jackson, Barry; Ban, Justin L.; Clendinnen, B G; Davidson, Warren D.; Thompson, James C.

doi:10.1097/00000658-197010000-00002

Cited by 151 publications

(52 citation statements)

References 11 publications

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“…Although studies reporting the effect of calcium on the increase in gastric acidity are intense (2)(3)(4)7,8), other literature reports focus on either increased pepsinogen (3,7) or increased gastrin levels (2,9,10 (12). In contrast, we had no mortalities.…”

Section: Discussionmentioning

confidence: 53%

Do elevated blood calcium levels in patients with peptic ulcer facilitate perforation?

Kahramanca¹,

Anuk²,

Yıldırım³

2018

J Turgut Ozal Med Cent

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Aim: Calcium is primarily stored in bones in the body. The increase in blood calcium level due to primary or secondary causes leads to several impairments of the gastrointestinal system like nausea-vomiting, and peptic ulcer (PU). In this study, we want to compare and analyse the difference in blood calcium levels of patients who underwent surgery for peptic ulcer perforation (PUP) and were diagnosed with PU by endoscopy. Material and Methods: Between May 2012-January 2017, patients' data for PU disease were recorded and our study was planned retrospectively. Patients were seperated into two groups: Group1, who was operated for PUP; and Group2, who were administered medical therapy for PU. Blood calcium levels during admission, age, gender and drug history of patients were recorded. Study exclusion criteria were patients whose data were missing (n=113), patients who had metabolic bone disease, patients who had been using calcium channel blockers and who were administered anti-ulcer drugs. Results: Twenty-eight patients had PUP and 176 patients had PU disease. Group 1 had a lower mean age (p=0.017), and higher male gender rate (p<0.001). The mean calcium level of Group 1 was 9.7±0.6 mg/dl, while the mean calcium level of Group 2 was 8.8±0.7 mg/dl (p<0.001). Less than the cut-off value of 9.25, calcium showed a sensitivity of 78.6% and a specificity value of 73.1% between groups. Conclusion: In our study, we found that in patients with PU diagnoses, elevated levels of calcium found in controls may increase both stomach acidity and the risk of PUP.

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Section: Discussionmentioning

confidence: 53%

Do elevated blood calcium levels in patients with peptic ulcer facilitate perforation?

Kahramanca¹,

Anuk²,

Yıldırım³

2018

J Turgut Ozal Med Cent

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“…If glucagon inhibits gastrin synthesis, the antral gastrin concentration will not increase so markedly as we observed in this study. The mechanism involved is, at least in part, the decrease of plasma calcium concentration by glucagon, as calcium has been demonstrated by in vivo (Reeder et al 1970;Passaro et al 1972) and in vitro (Harty et al 1981) experiments to be an important factor in the regulation of gastrin release.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of decrease of plasma gastrin by glucagon in man.

Nakanome

Ishimori

Gotō

et al. 1983

Tohoku J. Exp. Med.

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Exogenously administered glucagon causes a decrease of plasma gastrin concentration, but the mechanism has not been fully elucidated. We measured antral gastrin concentrations and plasma gastrin levels before and during glucagon infusion in nine patients free of gastrointestinal diseases. In addition, we measured plasma gastrin levels in both the renal artery and renal vein in six patients with normal renal function before and during glucagon infusion. Glucagon caused a significant increase of antral gastrin concentration concomitant with a significant decrease of plasma gastrin level and a significant decrease of percent extraction of gastrin in the kidney. These observations suggest that glucagon causes the decrease of plasma gastrin level by inhibiting the release of gastrin from the antrum, but not by accelerating the renal extraction of gastrin.-antral gastrin concentration; renal extraction; glucagon Exogenous administration of glucagon causes a decrease of basal or postprandial plasma gastrin concentration (Becker et al. 1973;Hansky et al. 1973), as well as of gastric acid secretion in man (Dreiling and Janowitz 1959;Solomon and Spiro 1959;Dotevall and Westling 1960;Cohen et al. 1960;Konturek et al. 1975;Christiansen et al. 1976). The mechanism of the inhibitory effect of glucagon on acid secretion could be, at least in part, due to decreasing plasma gastrin concentration (Christiansen et al. 1976). However, the mechanism of the decrease of plasma gastrin concentration by glucagon in man has not been fully elucidated.Possible mechanisms concerning the diminution of plasma gastrin concentration by glucagon are that glucagon inhibits gastrin synthesis, or inhibits gastrin release, or accelerates gastrin metabolism. The decrease of postprandial gastrin concentration by glucagon suggests that glucagon inhibits gastrin release. On the other hand, the possibility that glucagon accelerates renal extraction of

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“…In the dog, however, the serum gastrin concentration did ' not change during infusion of calcium (Reeder et al, 1970). On the contrary, some inhibition of gastric acid secretion may occur (Allen & Elliott, 1971).…”

Section: Introductionmentioning

confidence: 99%

The Influence of Hypercalcemia on Gastric Secretion and Serum Gastrin Concentration in Intact and Thyro-parathyroidectomized Rats

Johansson¹,

Krause²,

Nilsson³

et al. 1974

Upsala Journal of Medical Sciences

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Influence of Hypercalcemia on Gastric Secretion and Serum Gastrin Concentrations in Man

Cited by 151 publications

References 11 publications

Do elevated blood calcium levels in patients with peptic ulcer facilitate perforation?

Do elevated blood calcium levels in patients with peptic ulcer facilitate perforation?

Characteristics of decrease of plasma gastrin by glucagon in man.

The Influence of Hypercalcemia on Gastric Secretion and Serum Gastrin Concentration in Intact and Thyro-parathyroidectomized Rats

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