What are the education-to-work transition experiences of graduate creative professionals in a time when user-generated content is radically changing the organisations in which they will work? 60Sox is an online creative ecology for these emerging professionals that attempts to answer this question, in the process of showcasing and developing their creative and generic career capacities. We report here on the development and operation of 60Sox.org.au , and argue for its significance in terms of: (1) the centrality of human capital arguments in the operation of the creative economy; (2) the importance of ‘creative ecologies’ as an emerging business concept, particularly in the digital industries; (3) the arrival of online and peer-to-peer (p2p) architecture as a changing distribution mode within the digital content industries; (4) the related importance of pro-am creativity; and (5) the recognition of skill shortages and training requirements in Australia's digital content industries.
Three new fluorescent 7-deaza-2′-deoxyadenosine analogs were synthesized via the Sonogashira cross-coupling reaction of 7-iodo-7-deaza-2′-deoxyadenosine with 1-ethynylpyrene, 2-ethynyl-6-methoxynaphthalene, and 9-ethynylphenanthrene. The spectral properties of these analogs were evaluated in dioxane, EtOH, and H2O to determine their potential for use as environmentally sensitive fluorescent probes. All three analogs displayed large solvatofluorochromicity in H2O, relative to their emission wavelengths in dioxane or EtOH. Moreover, all three analogs exhibited microenvironmental sensitivity of their fluorescence emission intensity, being moderate to high quantum yields in dioxane and EtOH and significantly lower in H2O. Various attempts to perform domino cross-coupling and annuation reactions on 7-deaza-7-alkynyladenine derivatives to form a new fused tricyclic adenine analog were unsuccessful.
ETHICAL GUIDELINES FOR ENDOSCOPY Any discussion of medical ethics, including ethics and gastrointestinal endoscopy, must include four principles: autonomy, beneficence, nonmaleficence and justice. Autonomy is 'self-ruling'. Beneficence means kindness, to be charitable and beneficial. This special medical obligation is implicit in the doctor-patient therapeutic relationship. Nonmaleficence from an ethical view may not mean to do no harm but rather to make sure the anticipated harm or risks of therapy are worthwhile relative to the good intended from the patient's point of view. Justice requires fair treatment of patients and a respect for their rights. When reviewing the ethics of any aspect of endoscopy, it is worthwhile to keep the four principles in mind. Endoscopists must always consider the patient's best interests, especially in today's economic times when resource allocation and utilization are restricted. Knowing that their decisions will influence the health care budget at an aggregate or provincial level, the hospital budget at an intermediate level and the patient's budget at a microlevel, endoscopists must attend to their patients' needs and requirements, while doing no harm, all in the context of limited resources. Resources influence endoscopy. The cost per unit of endoscopy is calculable but these group goals may conflict with individual goals. Part of the financial equation is the professional's remuneration. To be paid for services rendered is morally correct and endoscopists must convince the general public of this. Diagnostic and therapeutic safety is foremost. This implies formal training and maintenance of competence. Endoscopists must have good standards of care. Despite lack of funding and more physicians wanting to do endoscopy, training for technical and cognitive skills is mandatory. Endoscopy is not solely guiding the endoscope. After a formal training program, competence must be maintained. Short courses in endoscopy do not replace a recognized formal pro-This consensus document was prepared on behalf of the Canadian Association of Gastroenterology
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