The Northwestern University SuperAging Project recruits community dwellers over the age of 80 who have unusually high performance on tests of episodic memory. In a previous report, a small cohort of SuperAgers was found to have higher cortical thickness on structural MRI than a group of age-matched but cognitively average peers. SuperAgers also displayed a patch of ACC where cortical thickness was higher than in 50- to 60-year-old younger cognitively healthy adults. In additional analyses, some SuperAgers had unusually low densities of age-related Alzheimer pathology and unusually high numbers of von Economo neurons in the anterior cingulate gyrus. SuperAgers were also found to have a lower frequency of the ε4 allele of apolipoprotein E than the general population. These preliminary results show that above-average memory capacity can be encountered in advanced age. They also offer clues to potential biological factors that may promote resistance to age-related involutional changes in the structure and function of the brain.
Background and Purpose Collateral flow can determine ischemic core and tissue at risk. Using the Interventional Management of Stroke (IMS) III Trial data, we explored the relationship between CT angiogram (CTA) collateral status and CT perfusion (CTP) parameters. Methods Baseline CTA collaterals were trichotomized as good, intermediate and poor and CTP studies were analyzed to quantify ischemic core, tissue at risk and mismatch ratios. Kruskal-Wallis and Spearman tests were used to measure the strength of association and correlation between CTA collaterals and CTP parameters. Results A total of 95 patients had diagnostic CTP studies in the IMS III trial. Of these, 53 patients had M1/M2 middle cerebral artery ± intracranial internal carotid artery occlusion, where baseline CTA collateral grading was performed. CTA collaterals were associated with smaller CTP measured ischemic core volume (p=0.0078) and higher mismatch (p=0.0004). There was moderate negative correlation between collaterals and core (rs =−0.45, 95% CI (−0.64, −0.20) and moderate positive correlation between collaterals and mismatch (rs =0.53, 95% CI (0.29, 0.71). Conclusion Better collaterals were associated with smaller ischemic core and higher mismatch in the IMS III trial. Collateral assessment and perfusion imaging identify the same biological construct regarding ischemic tissue sustenance.
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