This paper presents a smartphone-based binaural hearing aid architecture for improving the speech intelligibility of hearing aid users. The proposed system consists of an earpiece, a smartphone and an application that performs real-time speech enhancement. The speaker's voice, which is picked up by the microphone of the earpiece that is worn on the ear, is transmitted to the smartphone via wireless technology. After the speech intelligibility is improved in real time by the deep learning speech enhancement application, it is returned to the earpiece and generates sound. Deep learning speech enhancement algorithms can be used without performing burdensome calculations on the processors in the hearing aid. The results showed that the average usage of the central processing unit in the smartphone was approximately 26%, and the signal-tonoise ratios improve by at least 20%. The presented objective and subjective results show that the proposed method achieves comparatively more noise suppression without distorting the audio. INDEX TERMS Binaural hearing aids, smartphone, real-time se app, e-health, deep learning.
Buthus martensii Karsch (BmK), is a kind of traditional Chinese medicine, which has been used for a long history for the treatment of many diseases, such as inflammation, pain and cancer. In this study, DKK-SP1/2/3 genes were screened and extracted from the cDNA library of BmK. The DKK-SP1/2/3 were expressed by using plasmid pSYPU-1b in E. coli BL21, and recombinant proteins were obtained by column chromatography. In the xylene-induced mouse ear swelling and carrageenan-induced rat paw swelling model, DKK-SP1 exerted a significant anti-inflammatory effect by inhibiting the expression of Nav1.8 channel. Meanwhile, the release of pro-inflammatory cytokines (COX-2, IL-6) was decreased significantly and the release of anti-inflammatory cytokines (IL-10) were elevated significantly. Moreover, DKK-SP1 could significantly decrease the Nav1.8 current in acutely isolated rat DRG neurons. In the acetic acid-writhing and ION-CCI model, DKK-SP2 displayed significant analgesic activity by inhibiting the expression of the Nav1.8 channel. Moreover, DKK-SP2 could significantly inhibit the Nav1.7 current in the hNav1.7-CHO cells.
Due to the great advantages of high thermal conductivity and strong heat exchange capacity, nanofluids have attracted great intrest in many heat exchange fields, such as thermal power plant, solar energy, automobile cooling, nuclear power facilities and so on. In this paper, it reviews the research progress of nanofluids including preparation process, suspension stability, thermal conductivity, viscosity,and gives emphasis to analyse the influence factor of nanofluid convective heat transfer.
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