Long-read sequencing is promising for the comprehensive discovery of structural variations (SVs). However, it is still non-trivial to achieve high yields and performance simultaneously due to the complex SV signatures implied by noisy long reads. We propose cuteSV, a sensitive, fast, and scalable long-read-based SV detection approach. cuteSV uses tailored methods to collect the signatures of various types of SVs and employs a clustering-and-refinement method to implement sensitive SV detection. Benchmarks on simulated and real long-read sequencing datasets demonstrate that cuteSV has higher yields and scaling performance than state-ofthe-art tools. cuteSV is available at https://github.com/tjiangHIT/cuteSV.

Millimeter-wave multi-input multi-output (mm-Wave MIMO) systems are one of the candidate schemes for 5G wireless standardization efforts. In this context, the main contributions of this article are threefold. 1) We describe parallel sets of measurements at identical transmit-receive location pairs with 2.9, 29 and 61 GHz carrier frequencies in indoor office, shopping mall, and outdoor settings. These measurements provide insights on propagation, blockage and material penetration losses, and the key elements necessary in system design to make mm-Wave systems viable in practice. 2) One of these elements is hybrid beamforming necessary for better link margins by reaping the array gain with large antenna dimensions. From the class of fully-flexible hybrid beamformers, we describe a robust class of directional beamformers towards meeting the high data-rate requirements of mm-Wave systems. 3) Leveraging these design insights, we then describe an experimental prototype system at 28 GHz that realizes high data-rates on both the downlink and uplink and robustly maintains these rates in outdoor and indoor mobility scenarios. In addition to maintaining large signal constellation sizes in spite of radio frequency challenges, this prototype leverages the directional nature of the mm-Wave channel to perform seamless beam switching and handover across mm-Wave base-stations thereby overcoming the path losses in non-line-of-sight links and blockages encountered at mm-Wave frequencies. Index TermsMillimeter-wave, experimental prototype, MIMO, channel measurements, beamforming, handover, RF.

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