BWL was the most important risk factor for the compliance of adjuvant chemotherapy with S-1 in the patients with stage 2/3 gastric cancer who underwent D2 gastrectomy. To improve drug compliance that leads to survival, it is a key to maintain body weight before starting S-1 adjuvant. Our study emphasizes the requirement for adequate studies of perioperative nutritional intervention in patients who receive gastrectomy for advanced gastric cancer.
These results suggest that MDCT provides an accurate diagnosis with high specificity and a low false-positive rate and can be used to select the patients who are candidates for preoperative chemotherapy.
BackgroundEnhanced recovery after surgery (ERAS) programs have been reported to be feasible and useful for maintaining physiological function and facilitating recovery after colorectal surgery. The feasibility of such programs in gastric surgery remains unclear. This study assessed whether an ERAS program is feasible in patients who undergo gastric surgery.MethodsThe subjects were patients who underwent gastric surgery between June 2009 and February 2011 at the Department of Gastrointestinal Surgery, Kanagawa Cancer Center. They received perioperative care according to an ERAS program. All data were retrieved retrospectively. The primary end point was the incidence of postoperative complications. The secondary end point was postoperative outcomes.ResultsA total of 203 patients were studied. According to the Clavien-Dindo classification, the incidence of ≥ grade 2 postoperative complications was 10.8% and that of ≥ grade 3 complications was 3.9%. Nearly all patients did not require delay of meal step-up (95.1%). Only 6 patients (3.0%) underwent reoperation. The median postoperative hospital stay was 9 days. Only 4 patients (2.0%) required readmission. There was no mortality.ConclusionsOur results suggest that our ERAS program is feasible in patients who undergo gastric surgery.
A series of tetrahydronaphthyridine derivatives as novel RORγt inverse agonists were designed and synthesized. We reduced the lipophilicity of tetrahydroisoquinoline compound 1 by replacement of the trimethylsilyl group and SBDD-guided scaffold exchange, which successfully afforded compound 7 with a lower log D value and tolerable in vitro activity. Consideration of LLE values in the subsequent optimization of the carboxylate tether led to the discovery of [ cis-3-({(5 R)-5-[(7-fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic acid, TAK-828F (10), which showed potent RORγt inverse agonistic activity, excellent selectivity against other ROR isoforms and nuclear receptors, and a good pharmacokinetic profile. In animal studies, oral administration of compound 10 exhibited robust and dose-dependent inhibition of IL-17A cytokine expression in a mouse IL23-induced gene expression assay. Furthermore, development of clinical symptoms in a mouse experimental autoimmune encephalomyelitis model was significantly reduced. Compound 10 was selected as a clinical compound for the treatment of Th17-driven autoimmune diseases.
Photoirradiation of dibenzoyldiazomethane (DBDM) produced highly
electrophilic benzoylketene via Wolff
rearrangement. DBDM derivative possessing an aminoalkyl side chain
induced a DNA cleavage selectively at guanine
(G) residues upon photoirradiation and subsequent piperidine treatment.
In order to devise photochemical DNA
cleavers that can specifically alkylate a guanine residue proximal to
the target sequence of long DNA fragments, a
new reagent, DBDM-OSu, which facilitates the connection of DBDM unit to
various DNA binders, was developed.
DBDM-oligonucleotide (ODN) conjugates 5 and
6 were obtained by the coupling of 5‘-aminohexyl 8-mer
[H2N-(CH2)6-d(ACGTCAGG)-3‘] and 15-mer
[H2N-(CH2)6-d(ACGTCAGGTGGCACT)-3‘],
respectively, with DBDM-OSu in aqueous acetonitrile in the presence of sodium bicarbonate.
Photoirradiation of 5 and 6 in the presence
of
25-mer 5‘-d(AGTGCCACCTGACGTCTG18CTCTCTC)-3‘ having a
complementary sequence induced cross-linking
of both oligomers. A distinct cleavage band at guanine residue
(G18) was observed upon heating the
cross-linked
oligomers with piperidine. A similar DNA cleavage reaction of
5‘-d(AGTGCCACCTGACG14TG16CG18TG20CG22TCT)-3‘ having multiple guanine sites in the presence of DBDM-ODN
conjugate 6 indicated that the most effectively
cleaved site is G16. These results demonstrated that
DBDM-oligonucleotide conjugates can serve as a new class
of
photonucleases that can cleave single-stranded DNA at predetermined
guanine sites. Furthermore, the reagent DBDM-OSu can be used as a convenient and effective photoinducible
electrophile for the cross-linking or the modification
of biopolymers.
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