The purpose of this study was to determine the ocular, sex- and age-specific, anthropometric, and hematologic factors that affect the implicit times and amplitudes of the flicker ERGs recorded with the RETeval system from individuals 40- to 89-years-of-age. Flicker ERGs were recorded with the RETeval system from 330 individuals who had normal fundus and OCT images. Univariate and multivariate regression analyses were performed to identify factors associated with the implicit times and amplitudes of the RETeval flicker ERGs. Univariate regression analyses showed significant correlations between the implicit times and the BCVA, age, axial length, blood sugar level, and BUN in both eyes. Multivariate regression analyses identified age and axial length as two independent factors that were significantly correlated with the implicit times of the RETeval flicker ERGs. Univariate regression analyses also showed significant correlations between the amplitudes and age, platelet count, HDL level, and creatinine level in both eyes. However, smoking habits, body mass index, and blood pressure were not correlated with the RETeval flicker ERGs. We conclude that age and some ophthalmologic and hematologic findings except for anthropometric findings were suggested to significantly affect the measurements of the RETeval flicker ERGs.
Purpose To determine the factors significantly associated with the amplitudes and implicit times of the flicker electroretinograms (ERGs) recorded with the RETeval system by analyzing the comprehensive data obtained during a health checkup screening. Methods Flicker ERGs were recorded with the RETeval system from 373 individuals who had a normal fundus and optical coherence tomography images. The sex, age, anthropometric, ophthalmologic, and hematologic data were collected from all participants who were 40- to 89-years-of-age. Univariable and multivariable linear mixed effects regression analyses were performed to identify factors that were significantly associated with the implicit times and amplitudes of the RETeval flicker ERGs. Results Univariable linear mixed effects regression analysis showed significant correlations between the implicit times and the best-corrected visual acuity, the age, the axial length, the blood sugar level, and the blood urea nitrogen level. Analyses by multivariable linear mixed effects regression identified that the axial length (β = 0.28), the age (β = 0.24), and the blood sugar level (β = 0.092) were three independent factors that were significantly correlated with the implicit times of the RETeval flicker ERGs. Univariable linear mixed effects regression analysis also showed significant correlations between the amplitudes of the RETeval flicker ERGs and the age, the platelet count, and the creatinine level. Multivariable linear mixed effects regression models identified the age (β = -0.092), the platelet count (β = 0.099), and the creatinine level (β = -0.12) as three independent factors that were significantly correlated with the amplitudes of the RETeval flicker ERGs. However, the smoking habits, body mass index, and the blood pressure were not significantly correlated with either the implicit times or amplitudes of the RETeval flicker ERGs. Conclusions Our results indicate that the age and some ophthalmologic and hematologic findings but not the anthropometric findings were significantly associated with the implicit times and amplitudes of the RETeval flicker ERGs. Thus, clinicians should remember these factors when analyzing the RETeval flicker ERGs.
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