This study aimed to determine whether modulation of the gut microbiota structure by liraglutide helps improve nonalcoholic fatty liver disease (NAFLD) in rats on a high-fat diet (HFD). Rats were administered an HFD for 12 weeks to induce NAFLD and then administered liraglutide for 4 additional weeks. Next-generation sequencing and multivariate analysis were performed to assess structural changes in the gut microbiota. Liraglutide attenuated excessive hepatic ectopic fat deposition, maintained intestinal barrier integrity, and alleviated metabolic endotoxemia in HFD rats. Liraglutide significantly altered the overall structure of the HFD-disrupted gut microbiota and gut microbial composition in HFD rats in comparison to those on a normal diet. An abundance of 100 operational taxonomic units (OTUs) were altered upon liraglutide administration, with 78 OTUs associated with weight gain or inflammation. Twenty-three OTUs positively correlated with hepatic steatosis-related parameters were decreased upon liraglutide intervention, while 5 OTUs negatively correlated with hepatic steatosis-related parameters were increased. These results suggest that liraglutide-mediated attenuation of NAFLD partly results from structural changes in gut microbiota associated with hepatic steatosis.
Background: To determine the relationship between gestational diabetes mellitus (GDM) and coagulation/ brinolysis abnormality in antenatal Chinese women. Methods: Case control study. Fifty women had GDM and 132 did not (the NGDM group) grouping by the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Maternal plasma biochemistry and previous medical history were collected from perinatal health records. Antenatal coagulation/ brinolysis activity(CFA) parameters was assessed using thromboelastography and routine CFA parameters respectively. Univariate and multiple regression analyses were used to evaluate the associations between GDM and CFA parameters. Results: The women with GDM were signi cantly older than those without GDM (30.3 vs. 28.6 years, P=0.012). Compared with the NGDM group, the GDM group had a signi cantly higher prevalence of cesarean delivery (56.0% vs. 37.9%, P=0.027) and higher values of brinogen (FIB) (4.7vs. 4.3 g/L P=0.001), activated partial thromboplastin time (APTT) (30.9 vs. 29.5 seconds P=0.010).There were no signi cant differences in the prevalence of maternal thrombotic events or neonatal events.GDM was signi cantly associated with higher APTT (β 1.41seconds, 95% CI 0.29-2.53), FIB (β 0.38g/L, 95% CI 0.14-0.61), and percentage reduction in clot lysis after 30 min(LY30)(β 1.14%, 95% CI 0.15-2.13) after adjustment for potential confounding factors. Conclusions: GDM is signi cantly associated with hypercoagulability and secondary hyper brinolysis in these antenatal Chinese women.has been no assessment of the relationship between GDM and CFA, assessed using TEG, in pregnant Chinese women. Therefore, in this study, we aimed to evaluate the relationship between GDM and measures of CFA, after adjustment for potential confounding factors.
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