Inductive power transfer (IPT) system is widely used in material handling. A typical structure of the system takes an H-bridge inverter with an inductor-capacitor-inductor (LCL) resonant filter to realize a constant track current supplying changeless energy to the second side. However, the output voltage total harmonic distortion (THD) of the inverter increases, which causes the increase of output current circulation, when using voltage width control method to eliminate source voltage fluctuating. Therefore, a two-stage converter is proposed to optimize the output current circulation. The two-stage IPT system is composed of a boost converter cascaded with an H-bridge resonant inverter. The boost converter is employed to provide a higher and stable DC bus voltage. The H-bridge resonant inverter operates in a fixed width with a constant switching frequency. With the proposed topology, the THD of the high frequency voltage maintains the minimum value to realize minimum output current circulation in the LCL filter. The soft switching is realized to reduce the losses. Furthermore, expressions of coil and track model are presented by combining the theoretical analysis and finite element analysis (FEA). The experimental results show that over 76.6% efficiency is demonstrated in conditions of an 800 W load at the 14% source voltage fluctuation and the maximum efficiency was 78.6 %. The range of efficiency variation was 2% compared to a full-bridge system with voltage pluse-width control of which was 4.6%. INDEX TERMS Inductive power transfer (IPT), material handling, THD optimization, soft switching, finite element analysis (FEA).
Mitochondrial 12S rRNA A1555G and C1494T mutations are the major contributors to hearing loss. As patients with these mutations are sensitive to aminoglycosides, mutational screening for 12S rRNA is therefore recommended before the use of aminoglycosides. Most recently, we developed a novel multiplex allele-specific PCR (MAS-PCR) that can be used for detecting A1555G and C1494T mutations. In the present study, we employed this MAS-PCR to screen the 12S rRNA mutations in 500 deaf patients and 300 controls from 5 community hospitals. After PCR and electrophoresis, two patients with A1555G and one patient with C1494T were identified, this was consistent with Sanger sequence results. We further traced the origin of three Chinese pedigrees. Clinical evaluation revealed variable phenotypes of hearing loss including severity, age at onset and audiometric configuration in these patients. Sequence analysis of the mitochondrial genomes from matrilineal relatives suggested the presence of three evolutionarily conserved mutations: tRNACys T5802C, tRNALys A8343G and tRNAThr G15930A, which may result the failure in tRNAs metabolism and lead to mitochondrial dysfunction that was responsible for deafness. However, the lack of any functional variants in GJB2, GJB3, GJB6 and TRMU suggested that nuclear genes may not play active roles in deafness expression. Hence, aminoglycosides and mitochondrial genetic background may contribute to the clinical expression of A1555G/C1494T-induced deafness. Our data indicated that the MAS-PCR was a fast, convenience method for screening the 12S rRNA mutations, which was useful for early detection and prevention of mitochondrial deafness.
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