A substituent-controlled chemoselective cycloaddition reaction which afforded a variety of 2-pyridones and 4-pyridones in good to excellent yields, respectively, has been developed.
A one-pot method for the selective
synthesis of two isomers 4H-chromene and 2,8-dioxabicyclo[3.3.1]nonane
derivatives
was developed without a catalyst and using EtOH/H2O (4:1,
v/v) as the solvent. The reaction was conducted under mild conditions,
with forming multiple chemical bonds in one pot and high atom economy,
and only a stoichiometric amount of H2O is produced as
the byproduct. Its selectivity was controlled by thermodynamics and
kinetics, and the reasons for the transformation of the two structures
are also discussed.
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