IgG staining in human vagus nerves; H&E and Na v 1.7 expression in mouse sciatic nerves; tryptic digestion experiments for Hsp1a and Hsp1a-FL; epifluorescence images of sciatic nerves injected with Hsp1a-FL, block, or PBS, and the fluorescence quantification; fresh tissue confocal fluorescence microscopy (PDF) The authors declare the following competing financial interest(s): J.G., P.D.S.F., G.F.K. and T.R. are co-inventors on a Hsp1a-related patent application. S.K. and T.R. are shareholders of Summit Biomedical Imaging, LLC.
A multifunctional chlorin platform appended with four short polyethylene glycols and a carboxylate-linker allows rapid conjugation to biotargeting motifs such as proteins and oligonucleotides. The stability and photophysical properties of the chlorin enable development of diagnostics, imaging, molecular tracking, and theranostics.
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