Chemokine (C-X3-C motif) ligand 1 (CX3CL1, also known as fractalkine) and its receptor chemokine (C-X3-C motif) receptor 1 (CX3CR1) are widely expressed in immune cells and non-immune cells throughout organisms. However, their expression is mostly cell type-specific in each tissue. CX3CR1 expression can be found in monocytes, macrophages, dendritic cells, T cells, and natural killer (NK) cells. Interaction between CX3CL1 and CX3CR1 can mediate chemotaxis of immune cells according to concentration gradient of ligands. CX3CR1 expressing immune cells have a main role in either pro-inflammatory or anti-inflammatory response depending on environmental condition. In a given tissue such as bone marrow, brain, lung, liver, gut, and cancer, CX3CR1 expressing cells can maintain tissue homeostasis. Under pathologic conditions, however, CX3CR1 expressing cells can play a critical role in disease pathogenesis. Here, we discuss recent progresses of CX3CL1/CX3CR1 in major tissues and their relationships with human diseases.
• Transcatheter arterial Embolisation (TAE) is a safe and effective treatment for lower gastrointestinal tract haemorrhage. • Superselective embolisation is essential to improve outcomes. • N-butyl cyanoacrylate (NBCA) appears to be a preferred embolic agent with better clinical outcomes.
The seismicity in the Korean Peninsula has increased since the 2011 Mw9.0 Tohoku‐Oki megathrust earthquake. Two strike‐slip earthquakes with magnitudes of ML5.1 and 5.8 occurred in the southeastern Korean Peninsula on 12 September 2016. The two events occurred within 48 min. The ML5.8 earthquake was the largest event in the Korean Peninsula since 1978 when national seismic monitoring began. Both events produced strong high‐frequency ground motions. More than 500 aftershocks with local magnitudes greater than or equal to 1.5 followed the events for 2 months. An unreported subsurface strike‐slip fault with a dip of 65° to the east and a strike of N27°E was responsible for the earthquakes. The fault ruptured at depths of 11–16 km, resulting in a rupture plane of ∼26 km2. The aftershock distribution displayed horizontal streaks at a depth of ∼14 km, which was consistent with the focal mechanism solutions from long‐period waveform inversion. The number of aftershocks decreased exponentially with time. The two ML5.1 and 5.8 earthquakes produced regional Coulomb stress changes of −4.9 to 2.5 bar. The spatial distribution of the aftershocks correlated with the Coulomb stress changes. The peak dynamic stress induced by strong ground motions reached 14.2 bar. The groundwater levels changed coseismically in some regions of decreased static stresses. The earthquakes on previously unidentified faults raised attention for the potential seismic hazards by earthquakes with long recurrence intervals.
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