Multiple myeloma is a fetal form of plasma cell malignancy characterized by abnormal clonal proliferation of plasma cells. Especially, the canonical Wnt signaling pathway mediated by β-catenin is activated in multiple myeloma cells, stimulating their proliferation. Here, we investigated the relationship between interleukin-6-induced proliferation of multiple myeloma cells and Traf2- and Nck-interacting kinase (TNIK) expression in Wnt signaling. Interleukin-6 increased the proliferation of multiple myeloma cells and TNIK mRNA and protein expression. In addition, we examined the effect on TNIK of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib and whether inhibition of TNIK suppresses the interleukin-6-induced proliferation of multiple myeloma cells. KY-05009 and dovitinib synergistically inhibited interleukin-6-stimulated proliferation and induced apoptosis through the inhibition of Wnt signaling in MM cells. Our results provide crucial information that TNIK is involved in the interleukin-6-dependent proliferation of multiple myeloma cells and inhibition of Wnt signaling involving TNIK could be a therapeutic strategy for the treatment of interleukin-6-dependent multiple myeloma.

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In this paper, we propose a method for generating a realistic object panorama by considering geometric transformations of camera views in a general photographing environment. In the proposed method, we first model a trumpet-shape panorama space based on geometric transformations of camera, such as vertical rotation and horizontal rotation movement around a target model. We then generate an object panorama by mapping model images to the trumpet-shape panorama space. To evaluate the performance of the proposed method, experiments were conducted on a large size model, which is quite difficult for us to generate the object panorama without special equipments in general. The experimental results show that the proposed method can effectively generate an object panorama, which is usually generated in a special photographing environment, regardless of the size of target model.