Many early-career researchers are involved in the peer review of manuscripts for scientific journals, typically under the guidance of or jointly with their advisor, but most of the evidence about this activity is anecdotal. Here we report the results of a literature review and a survey of researchers, with an emphasis on co-reviewing and 'ghostwriting'. The literature review identified 36 articles that addressed the involvement of early-career researchers in peer review, most of them about early-career researchers and their advisors co-reviewing manuscripts for the purposes of training: none of them addressed the topic of ghostwriting in detail. About three quarters of the respondents to the survey had co-reviewed a manuscript. Most respondents believe co-reviewing to be a beneficial (95%) and ethical (73%) form of training in peer review. About half of the respondents have ghostwritten a peer review report, despite 81% responding that ghostwriting is unethical and 82% agreeing that identifying co-reviewers to the journal is valuable. Peer review would benefit from changes in both journal policies and lab practices that encourage mentored co-review and discourage ghostwriting.

The goal of this study is to shed light on the involvement of early career researchers (ECRs) during peer review of manuscripts for publication in journals. In particular, we sought to better understand how commonly ECRs contribute ideas and/or text to peer review reports when they are not the invited reviewer ("coreview"), and how commonly ECRs do not receive named credit to the journal editorial staff for these scholarly efforts ("ghostwrite"). First, we evaluated 1,952 publications in the peerreviewed literature generated by exhaustive search terms that combined synonyms of "early career researcher" and "peer re view" and found no previous studies about ECRs ghostwriting peer review reports. We then surveyed 498 researchers about their experiences with, and opinions about, coreviewing and ghostwriting as ECRs. Three quarters of those surveyed have coreviewed and most find it to be a beneficial (95% agree) and ethical (73% agree) form of training in peer review. Coreviewing is the second most commonly reported form of training in peer review besides receiving reviews on one's own papers. Half of survey respondents have ghostwritten a peer review report, despite the 4/5ths majority opinion that ghostwriting is unethical. Survey respondents report that the three major barriers to including coreviewer names on peer review reports are: a lack of communication between PIs and ECRs; a false belief that coauthorship is for manuscripts but not peer review reports; and prohibitive journal policies that are out of alignment with current practice and opinions about best practice. We therefore propose recommendations for changing this status quo, to discourage unethical ghostwriting of peer review reports and encourage quality coreviewing experiences as normal training in peer review. Abstract

An effective vaccine against Chlamydia trachomatis is urgently needed as infection rates continue to rise and C. trachomatis causes reproductive morbidity. An obligate intracellular pathogen, C. trachomatis employs a type 3 secretion system (T3SS) for host cell entry. The tip of the injectosome is composed of the protein CT584, which represents a potential target for neutralization with vaccine-induced antibody. Here, we investigate the immunogenicity and efficacy of a vaccine made of CT584 epitopes coupled to a bacteriophage virus-like particle (VLP), a novel platform for Chlamydia vaccines modeled on the success of HPV vaccines. Female mice were immunized intramuscularly, challenged transcervically with C. trachomatis, and assessed for systemic and local antibody responses and bacterial burden in the upper genital tract. Immunization resulted in a 3-log increase in epitope-specific IgG in serum and uterine homogenates and in the detection of epitope-specific IgG in uterine lavage at low levels. By contrast, sera from women infected with C. trachomatis and virgin controls had similarly low titers to CT584 epitopes, suggesting these epitopes are not systemically immunogenic during natural infection but can be rendered immunogenic by the VLP platform. C. trachomatis burden in the upper genital tract of mice varied after active immunization, yet passive protection was achieved when immune sera were pre-incubated with C. trachomatis prior to inoculation into the genital tract. These data demonstrate the potential for antibody against the T3SS to contribute to protection against C. trachomatis and the value of VLPs as a novel platform for C. trachomatis vaccines.

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