The aim of the present study was to evaluate the relative functional volume of bilateral lumbar multifidus (LM) muscles across different stages and ages of patients with lumbar disc herniation (LDH). The relative functional volumes of LM muscles in both non-affected and affected sides in the L4-L5 and L5-S1 segmental level were measured in a resting prone position, and visual analogue score (VAS) for pain and Japanese Orthopedic Association (JOA) scores were recorded. The correlation between changes in the relative net volume of LM muscles and times of onset, ages, VAS and JOA scores were analyzed. A total of 327 cases were selected. The affected sides of LM muscles could present a certain degree of atrophy in stages >3 weeks. During the duration of the course, all cases presented different degrees of LM muscle atrophy. In addition, the degree of LM muscle atrophy was positively correlated with its duration. Age could influence the degree of LM muscle atrophy. Patients with unilateral LDH had <10% asymmetry on relative functional volume in the youth group. At the L4-L5 segments, patients with unilateral LDH had >10% asymmetry within the course of 3 months in the elderly group. The reduced rate of the relative functional net LM muscle volume was positively correlated with VAS scores, age, duration and JOA scores. In conclusion, the reduced rate of relative functional net LM muscle volume was positively correlated with age, duration, VAS scores and JOA scores. Although these findings are unreliable markers of lumbar pathology in an individual level for use in clinical or research settings, there is a notable importance of early intervention in LM muscle atrophy.
Background: This study aims to evaluate the association between serum alkaline phosphatase (ALP), calcium (Ca) and phosphorus (P), C-reactive protein (CRP) and D-dimer (D-D), and hemoglobin (Hb) in postoperative and preoperative osteoporotic hip fracture elderly patients.Methods: A total of 32 operation patients with osteoporotic hip fracture over the age of 65 years old were admitted to the orthopedic unit and prospectively evaluated. All patients were treated according to specific protocols, according to the type of fracture. Fasting blood samples were taken, and serum ALP, Ca and P measurements were respectively performed in six periods: at the time of admission, post-operation, and at postoperative one week, two weeks, one month and three months. Hb, CRP and D-D were also analyzed, and the fracture healing was recorded.Results: Finally, 32 cases were selected for the present study. The analysis results revealed that the level of serum Ca and ALP slowly increased at two weeks after surgery, and slightly dropped back at three months after the operation. Furthermore, D-D and CRP had a significant effect at pre-and post-operation, and exhibited an obvious downward trend after postoperative one week. The fracture healing and recovery of activities were associated with the Hb levels. The serum levels of ALP, which were adjusted by Ca and P, were associated with Hb and CRP, but not with D-D.Conclusions: Interestingly, there was an association between CRP and D-D. These findings suggest that early control of inflammation and loss of Ca could play a positive role for the healing of osteoporotic hip fractures.
SummaryBy analyzing data from NHANES, we aimed to evaluate the prevalence, characteristics, and associated factors of wrist fractures in Americans aged 50 and above.IntroductionWrist fractures, whose prevalence increases with age, are one of the most common fractures in the United States. However, epidemiological studies on the prevalence of wrist fractures of certain ages were limited.MethodsThe data of Americans aged 50 or above from 2013–2014 and 2017–2018 in NHANES were extracted and analyzed.ResultsThe prevalence of wrist fractures among Americans whose age was 50 or above was 12%, which was similar between men and women (men 12.8% vs. women 11.4%, p = 0.267). Among those who had experienced their first wrist fracture, 17.8% of the population experienced a second wrist fracture. The top two causes of the first wrist fracture were a fall from a standing height (56%) or a hard fall (34.8%). The prevalence of wrist fractures was higher in men than in women (13.7% versus 8.7%, p = 0.023) aged < 60, but higher in women than in men aged ≥ 60 (11.8% versus 14.3%, p = 0.007). Multivariate analysis showed that obesity, frequent drinking, current smoking, high serum phosphate level, non-Hispanic white women, and osteoporosis were independently associated with wrist fractures. Stratified by race, osteoporosis, frequent drinking, and high serum phosphate level were risk factors for wrist fractures in all races. As for Mexican Americans, non-Hispanic whites, and other races including multi-racial, current smoking was a risk factor of wrist factures. Furthermore, obesity was positively associated with wrist fractures in Mexican Americans, other Hispanics, and non-Hispanic whites.ConclusionThe prevalence of wrist fractures in Americans aged 50 and above was 12%. Falling from a standing height was the main cause of the first wrist fracture. Frequent drinking, current smoker, high serum phosphate level, osteoporosis, obesity, and non-Hispanic women were more likely to experience wrist fractures.
BackgroundWrist fractures, also known as distal radius fractures, are the most common fractures occurred in the upper limb. This study is conducted in the purpose of evaluating the prevalence, characteristics, and associated factors of wrist fractures in Americans that aged 50 and above.MethodsData of Americans aged 50 or above from the year 2013 to 2014 and 2017 to 2018 in NHANES was extracted and analyzed. Based on orthopedist's diagnosis, we further conducted surveys to determine the condition of wrist fractures, and collected relevant epidemiological and demographic data. The prevalence of wrist fractures and other statistics were calculated to study population characteristics and analyze potential risk factors associated with wrist fractures.ResultsThe prevalence of wrist fractures among Americans whose age was 50 or above was 12%, with similar results between men and women patients (male 12.8 % vs female 11.4 %, P = 0.267). Male and female Americans’ first wrist fracture occurred at a mean age of 29.4. 17.8% of Americans aged 50 and above had experienced two fractures, while 1.7% of Americans even experienced four or more fractures. The top two causes of the first fracture were falling down from standing height (56%) and violent falls (34.8%). Multivariate analysis showed that osteoporosis (OR = 2.2, 95% CI = 1.7-2.9), excessive drinking (OR = 1.8, 95% CI = 1.3-2.4), smoking (OR = 1.6, 95% CI = 1.2-2.1), prednisolone administration (OR = 1.5, 95% CI = 1.1-2.1) and obesity (OR = 0.8, 95% CI = 0.6-0.9) were independently associated with wrist fractures. Gender was not an independent risk factor associated with wrist fractures.ConclusionsThe prevalence of wrist fractures in Americans aged 50 and above was 12 %. The prevalence was similar between male and female patients. Falling from a standing height was the main cause of the first wrist fracture. Osteoporosis, excessive drinking, smoking and prednisolone administration were risk factors of wrist fractures, while obesity was negatively correlated.
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