Without employing a photocatalyst or additive, a strategy has been developed for the visible-light-initiated regioselective sulfonylation/cyclization of 1,6-enynes in 2-methylTHF from sulfonyl chlorides under open-air conditions at room temperature.

A copper-catalyzed cascade cyclization of 1,6enynes with sulfonyl hydrazides for producing various sulfonyl-substituted γ-lactams is described. This sulfonyl radical-enabled cyclization reaction features excellent regioselectivity, mild conditions and broad substrate scope, enabling the formation of new CÀ S and CÀ C bonds through radical sulfonylation, intramolecular cyclization and hydrogen abstraction. Moreover, relevant experiments have been carried out to probe a possible mechanism.

A good regioselective, high atom-economical and transition-metal-free method for the synthesis of α-functionalized ether derivatives via the domino radical cyclization of 1,6-enynes is described.

Nowadays decentralized botnets pose a great threat to Internet. They evolve new features such as P2P Command and Control(C&C), which makes traditional detection methods no longer effective for indicating the existence of the bots. In this paper, based on several of the new P2P botnet characteristic properties, we propose a novel real-time detecting model – MSFM (Multi-Stream Fused Model). MSFM considers multiple types of packets’ unique characteristics and handle them with corresponding strategies. Extensive experiment results show that our model can accurately detect peer-to-peer botnet with relatively low false-positive and false-negative rates.

A new, efficient, and practical radical cyclization of olefinic amides with ketones through α-C(sp3)–H functionalization in the presence of tert-butyl peroxybenzoate (TBPB) is described for the first time. This protocol assembles a wide range of pivotal and useful benzoxazines in good to excellent yields under mild, catalyst-free, ligand-free, and base-free conditions with wide functional group tolerance. Moreover, the mechanistic study indicates that the α-carbonyl radical is involved in this transformation.