We describe 4 cases of gingival hyperplasia induced by nifedipine, together with clinical and histological findings. Hyperplasia of the interdental papillae was observed in all cases. Histologic examination showed multilayered epithelial parakeratosis with variations in the width, proliferation, reticulation and elongation of the rete pegs. Substitution of another drug and improvement of oral hygiene led to reduction of the gingival overgrowth without gingivectomy. These treatments are essential for gingival hyperplasia induced by nifedipine.

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We present a case involving an unusually large calculus of Wharton's duct. To gain insight into the formation of this calculus, detailed structural properties were investigated using an X-ray diffraction technique. A 70-year old man, brought a calculus to a dental consultation, by himself, when it pelforated the floor of the mouth. The calculus was unusually long, measuring 4.5 cm in length. X-ray diffraction and micro-FT-1R analyses were employed to investigate structural properties of the calculus, which suggested that its stratified structure, reflecting compositional changes in the microenvironment, was a result of intemuttent and incremental growth.

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