Stabilized net: A molecular design approach to protect a 2D hydrogen‐bonding network with nonpolar shielding layers has allowed the fabrication of micrometer‐scale supramolecular vesicles in water (see picture). These hydrogen‐bond‐directed giant vesicles and their dispersions in aqueous media show high stability under various conditions.

No abstract

Fluorescence‐based hydrogel glucose sensors with boronic acid‐based glucose recognition are promising regarding their potential to improve continuous glucose monitoring by facilitating long‐lasting accuracy. However, these sensors typically become encapsulated after implantation, and the dynamic range decreases following long‐term implantation and use. Herein, a four‐arm polyethylene glycol (PEG) hydrogel is developed with an immobilized glucose‐responsive fluorescence dye (GF‐PEG‐gel); this hydrogel is effective in mitigating foreign body reactions (FBRs) that hinder stable glucose responses in vivo. The GF‐PEG‐gel attached to an implantable device successfully traces blood glucose concentrations in diabetic model rats for 45 days. A pig experiment shows that the device measures the glucose concentration with an equivalent accuracy to that required for clinically available settings.

By mixing a small volume of THF containing guanosine derivative 1 and tetraethylenegrycol dodecyl ether (TEGDE) with water and subsequently removing TEGDE by gel permeation chromatography, micrometer-sized giant unilamellar vesicles (GUV) of 1 were successfully prepared. The vesicle membrane was a 2-D sheet assembly of thickness 2.5 nm, composed of a 2-D inter-guanine hydrogen-bond network. The GUV dispersion showed high stability because of a large negative zeta potential, which allowed repeated sedimentation and redispersion by centrifugation and subsequent gentle agitation. TEGDE-triggered fusion of GUVs took place within 350 ms, which proceeded by fusion of the vesicle membranes in contact. These unique static and dynamic properties of the GUV membrane assembled by the 2-D hydrogen-bond network are discussed.