Liver fibrosis is one of the common complications of transient myeloproliferative disorder (TMD) in Down syndrome (DS), but the exact molecular pathogenesis is largely unknown. We herein report a neonate of DS with liver fibrosis associated with TMD, in which we performed the serial profibrogenic cytokines analyses. We found the active monocyte chemoattractant protein-1 expression in the affected liver tissue and also found that both serum and urinary monocyte chemoattractant protein-1 concentrations are noninvasive biomarkers of liver fibrosis. We also showed a prospective of the future anticytokine therapy with herbal medicine for the liver fibrosis associated with TMD in DS.
A variety of individuals around the world are furthering development of Free/Libre/Open Source Software (FLOSS) through the Internet. Why do they participate in developers’ communities and continue to develop FLOSS? Is their treatment enough to sustain their activities? Surveys, using online questionnaires, were conducted to answer these questions to analyze the FLOSS movement sociologically. However these surveys tend to focus on developers in the West. We decided to see if there are regional differences in FLOSS development. To that end, we conducted two surveys, the FLOSS–JP survey in Japanese and the FLOSS–ASIA survey in other Asian languages. In this paper, we describe regional differences, especially among Asian and Japanese FLOSS developers and compare the results to those from Western FLOSS surveys. Detailed reports of FLOSS–JP/ASIA are available at our Web site (MRI, 2004)
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