The effects of various cooking methods on the physical and structural properties cooked rice, on the in vitro hydrolysis of the contained starch and on blood glucose response in rats were investigated. At optimum cooking state, a larger filamentous network was formed and most of the starch granules were fragmented, furthermore the samples heated by microwave and electric cooker showed a more compact structure compared to those treated in an autoclave or stone pot. The highest degree of gelatinization (DG) was observed in the sample treated in an autoclave (75.2%), followed by stone pot (71.1%), electric cooker (66.9%) and microwave oven (64.6%). The highest firmness (3.49 N) was observed in cooked rice heated by microwaves and no significant differences (p > 0.05) were found between the other samples. All cooked rice samples showed increased pasting temperatures and decreased peak viscosity compared to those of raw rice flour. The starch hydrolysis rates and their kinetic constants of cooked rice samples increased with increase in DG, and relatively higher values were observed in samples treated in the autoclave and stone pot. There was a significant difference in the blood glucose content depending on cooking methods, and the highest glucose level was observed in the sample heated by autoclaving.
LCB01-0648 is a novel oxazolidinone compound that shows potent antibacterial activities against most Gram-positive cocci, including the multi-drug resistant Staphylococcus aureus. In this study, in vivo activity of LCB01-0699, a LCB01-0648 prodrug, against S. aureus was evaluated in comparison with that of Linezolid. The results of the systemic infection study demonstrated that LCB01-0699 was more potent than Linezolid against methicillin-susceptible and -resistant S. aureus strains. The in vivo efficacy of LCB01-0699 against methicillin-susceptible and -resistant S. aureus strains in a skin infection model showed more potent activity than Linezolid. LCB01-0699 shows potent in vivo activity against methicillin-susceptible and -resistant S. aureus strains, suggesting that LCB01-0699 would be a novel candidate for the treatment of these infectious diseases caused by S. aureus.
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