A I M :To e v a l u a t e t h e e f f i c a c y a n d s a f e t y o f gemcitabine-oxaliplatin (GEMOX) combined with huachansu (cinobufagin) injection treatment in patients with locally advanced or metastatic gallbladder carcinoma (GBC), and to assess the quality of life (QOL) of such patients. METHODS: Twenty-five patients with locally advanced or metastatic GBC were treated with intravenous gemcitabine (1000 mg/m 2 ) over 30 min on days 1 and 8, 2 h infusion of oxaliplatin (120 mg/m 2 ) on day 1, and 2-3 h infusion of huachansu (20 mL/m 2 ) on days -3-11, every 3-4 wk. Treatment was continued until occurrence of unacceptable toxicity or disease progression. QOL of patients was assessed by the EORTC QLQ-C30 at baseline, at the end of the first, third and sixth chemotherapy cycles, and 1 mo after the treatment. RESULTS: Among the 25 patients with a median age of 64 years (range 42-78 years), 23 were evaluable in the study. A total of 137 cycles of therapy were performed and the median cycle was 5 (range 1-8) per patient. Out of the 23 patients whose response could be evaluated, 8 partial responses (PR) were observed (34.8%), while 7 patients (30.4%) demonstrated a stable disease (SD). The disease control rate was 65.2%. Progression of cancer was observed in 8 (34.8%) patients. The median progression-free and overall survival time was 5.8 mo (95% CI: 4.5-7.1 mo) and 10.5 mo, respectively. The therapy was well tolerated, with moderate myelosuppression as the main toxicity. Anemia grade 2 was seen in 16.0%, neutropenia grade 3 in 8.0% and thrombocytopenia grade 3 in 24.0% of patients, respectively. Nonhematologic toxicity ranged from mild to moderate. No death occurred due to toxicity. The QOL of patients was improved after chemotherapy, and the scores of QOL were increased by 10 to 20 points. CONCLUSION: GEMOX combined with huachansu (cinobufagin) injection is well tolerated, effective, thus improving the QOL of patients with advanced GBC.
Yellow croaker Larimichthys polyactis muscle oil was extracted using an environmental friendly solvent, supercritical carbon dioxide (SC-CO 2), in a semi-batch flow extraction process. SC-CO 2 was applied at temperature 35°C to 45°C and 150°C to 250°C bar of pressure. The flow rate of CO 2 (27.79 g/min) was constant throughout the entire 1.5 h extraction period. The oil extraction yield was influenced by the physical properties of SC-CO 2 at different temperatures and pressures. The extracted oil was analyzed by gas chromatography to determine the fatty acid composition. According to our results, the SC-CO 2 extracted oil was high in eicosapentaenoic acid and docosahexaenoic acid. In addition, the SC-CO 2 extracted oil showed greater stability than n-hexane extracted oil based on the peroxide value and acid value. Thus, the quality of yellow croaker oil obtained by SC-CO 2 extraction was slightly higher than that of oil obtained by n-hexane extraction.
Fig. 1. A 6-year-old girl with mesenteroaxial gastric volvulus. A. Erect simple abdomen radiography shows two large air fluid levels (arrows) in the left upper quadrant of the abdomen. B. UGI examination shows superomedially located gastric antrum with beak appearance (arrow) and inferiorly located gastric fundus. C. The gastric antrum (thick arrow) is seen at the superoanterior side of the esophagogastric junction (thin arrow) on transverse ultrasonographic scan. The gastric cardiac portion(thin arrow) connected with esophagogastric junction is crossing the gastric antrum (thick arrow) on a more inferior oblique transverse ultrasonographic scan. D. The gastric antrum (thick arrow) is seen at the superoanterior side of the esophagogastric junction (thin arrow) on axial CT images. E. The gastric cardiac portion (thin arrow) connected with esophagogastric junction is crossing the gastric antrum (thick arrow) on a more inferior image. F. Follow-up UGIS shows the normal gastric antral location and good passage of the contrast medium to the duodenum.
Address reprint requests to :Gastric volvulus is a rare condition, and it is classified as the organoaxial or mesentericaxial type according to the axis of rotation. We experienced 1 case of pediatric recurrent mesenteroaxial gastric volvulus and we report here the ultrasonographic and CT findings.
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