The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinylcarbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line were described. Among them, three compounds 1e, 1h, and 1o showed superior antiproliferative activities to Sorafenib (IC 50 = 5.5 µM) as a reference compound. In our series, urea compound 1o having 4-chloro-3-trifluoromethyl moiety on the benzene nucleus exhibited very good antiproliferative activity with IC 50 value of 1.4 µM.
Title compounds (Ia)—(Ic) exhibit superior antiproliferative activities against A375 human melanoma cell line compared to the reference drug Sorafenib.
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