The Korean horse mussel extract was purified and fractionated by a bioassay-guided purification step. The final fraction contained seven steroid and one polycyclic aromatic compounds, in which cholest-7-en-3-ol, (3b,5a)-(58.7 %) was a main component followed by ergosta-7,22dien-3-ol (3b,5a,22E) (13.0 %). This extract exhibited strong anti-inflammatory activity determined solely through the nitric oxide inhibition assay in a dose-dependant manner with the IC 50 value of 9.6 lg/mL and no cytotoxic effect on the macrophages. Moreover, it also exhibited strong cytotoxicity with the IC 50 values of 21.4, 36.4, and 37.1 lg/mL against AGS, DLD-1, and HeLa cells, respectively. These results indicated that the horse mussel extract might be a functional ingredient in the prevention of inflammation and human cancers.
and their reaction product peroxynitrite (ONOO-) may be generated in excess during the host response against viral and antibacterial infections and may contribute to pathogenesis by promoting oxidative stress, tissue injury and even cancer [3]. Marine organisms are excellent sources of structurally diverse molecules that are potentially valuable as drugs. Many natural marine products have been designated as sources of new anti-inflammatory factors and cancer chemopreventive agents [4]. In particular, the starfishes was considered as one of the most promising sources of such agents due to the variety of species and applications of its products. Starfish (sea star) is an invertebrate belonging to the class Asteroidea, phylum Echinodermata, of which over 1500 species are
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