Temporal triangular alopecia, also referred as congenital triangular alopecia, is
an uncommon dermatosis of unknown etiology. It is characterized by a
non-scarring, circumscribed alopecia often located unilaterally in the
frontotemporal region. It usually emerges at ages 2-9 years. Alopecia areata is
the main differential diagnosis, especially in atypical cases. Dermoscopy is a
noninvasive procedure that helps distinguish temporal triangular alopecia from
aloepecia areata. Such procedure prevents invasive diagnostic methods as well as
ineffective treatments.
Muir-Torre Syndrome is defined by the coexistence of sebaceous skin tumors and
internal malignancies. Mutations in the DNA mismatch repair genes are found in the
inherited form of the disease, resulting in the absence of crucial enzymes involved
with DNA replication process. This case describes a patient with sebaceous adenoma
and colorectal carcinoma, meeting the criteria for Muir-Torre Syndrome. The
immunohistochemical analysis of the skin lesion was an important tool to confirm the
diagnosis, as it revealed nuclear negativity for MSH2 and MSH6.
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