Point of care molecular diagnostics benefits from a portable battery-operated device capable of performing a fast turnaround using reliable inexpensive cartridges. We describe a prototype device for performing a molecular diagnostics test for clinical and biodefense samples in 16 minutes using a prototype capable of an 8 minute PCR reaction, followed by hybridization and detection on an electrochemical microarray based on the i-STAT® system. We used human buccal swabs for hemochromatosis testing including in-device DNA extraction. Additional clinical and biodefense samples included influenza A and bacterial select agents Bacillus anthracis, Yersinia pestis and Francisella tularensis.
the language, to accept my most sincere thanks. To Professor Niels Bohr, Copenhagen, I am indebted for useful remarks about the mathematical part. Finally, I have to express my great obligation to Mr W. D. Evans, M.A., who has read through the manuscript and proofs of the mathematical part and who has assisted me in various ways.
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