The human connectome project (HCP) relies primarily on three complementary magnetic resonance (MR) methods. These are: 1) resting state functional MR imaging (rfMRI) which uses correlations in the temporal fluctuations in an fMRI time series to deduce ‘functional connectivity’; 2) diffusion imaging (dMRI), which provides the input for tractography algorithms used for the reconstruction of the complex axonal fiber architecture; and 3) task based fMRI (tfMRI), which is employed to identify functional parcellation in the human brain in order to assist analyses of data obtained with the first two methods. We describe technical improvements and optimization of these methods as well as instrumental choices that impact speed of acquisition of fMRI and dMRI images at 3 Tesla, leading to whole brain coverage with 2 mm isotropic resolution in 0.7 second for fMRI, and 1.25 mm isotropic resolution dMRI data for tractography analysis with three-fold reduction in total data acquisition time. Ongoing technical developments and optimization for acquisition of similar data at 7 Tesla magnetic field are also presented, targeting higher resolution, specificity of functional imaging signals, mitigation of the inhomogeneous radio frequency (RF) fields and power deposition. Results demonstrate that overall, these approaches represent a significant advance in MR imaging of the human brain to investigate brain function and structure.

Sparse signal representation, analysis, and sensing have received a lot of attention in recent years from the signal processing, optimization, and learning communities. On one hand, learning overcomplete dictionaries that facilitate a sparse representation of the data as a liner combination of a few atoms from such dictionary leads to state-of-the-art results in image and video restoration and classification. On the other hand, the framework of compressed sensing (CS) has shown that sparse signals can be recovered from far less samples than those required by the classical Shannon-Nyquist Theorem. The samples used in CS correspond to linear projections obtained by a sensing projection matrix. It has been shown that, for example, a nonadaptive random sampling matrix satisfies the fundamental theoretical requirements of CS, enjoying the additional benefit of universality. On the other hand, a projection sensing matrix that is optimally designed for a certain class of signals can further improve the reconstruction accuracy or further reduce the necessary number of samples. In this paper, we introduce a framework for the joint design and optimization, from a set of training images, of the nonparametric dictionary and the sensing matrix. We show that this joint optimization outperforms both the use of random sensing matrices and those matrices that are optimized independently of the learning of the dictionary. Particular cases of the proposed framework include the optimization of the sensing matrix for a given dictionary as well as the optimization of the dictionary for a predefined sensing environment. The presentation of the framework and its efficient numerical optimization is complemented with numerous examples on classical image datasets.

This work presents quantitative prediction of severity of the disease caused by Phytophthora infestans in potato crops using machine learning algorithms such as multilayer perceptron, deep learning convolutional neural networks, support vector regression, and random forests. The machine learning algorithms are trained using datasets extracted from multispectral data captured at the canopy level with an unmanned aerial vehicle, carrying an inexpensive digital camera. The results indicate that deep learning convolutional neural networks, random forests and multilayer perceptron using band differences can predict the level of Phytophthora infestans affectation on potato crops with acceptable accuracy.

Modern non-invasive brain imaging technologies, such as diffusion weighted magnetic resonance imaging (DWI), enable the mapping of neural fiber tracts in the white matter, providing a basis to reconstruct a detailed map of brain structural connectivity networks. Brain connectivity networks differ from random networks in their topology, which can be measured using small worldness, modularity, and high-degree nodes (hubs). Still, little is known about how individual differences in structural brain network properties relate to age, sex, or genetic differences. Recently, some groups have reported brain network biomarkers that enable differentiation among individuals, pairs of individuals, and groups of individuals. In addition to studying new topological features, here we provide a unifying general method to investigate topological brain networks and connectivity differences between individuals, pairs of individuals, and groups of individuals at several levels of the data hierarchy, while appropriately controlling false discovery rate (FDR) errors. We apply our new method to a large dataset of high quality brain connectivity networks obtained from High Angular Resolution Diffusion Imaging (HARDI) tractography in 303 young adult twins, siblings, and unrelated people. Our proposed approach can accurately classify brain connectivity networks based on sex (93% accuracy) and kinship (88.5% accuracy). We find statistically significant differences associated with sex and kinship both in the brain connectivity networks and in derived topological metrics, such as the clustering coefficient and the communicability matrix.