Introduction: We examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity. Methods: A total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal 70

HighlightsWhite matter hyperintensity volume in association and projection tracts was related to memory in older adults.The relationship of WMH volumes in association and projection tracts with cognition was specific to memory, and not to a global cognition measure that excluded memory.Within projection tracts, WMH volumes affecting the anterior thalamic and the corticospinal tracts were most reliably associated with poorer memory.Within association tracts, WMH volume affecting the inferior fronto-occipital fasciculus, the superior longitudinal fasciculus, and the uncinate fasciculus were most reliably associated with poorer memory.

BACKGROUND AND PURPOSE: White matter hyperintensities on T2-weighted MR imaging are typical in older adults and have been linked to several poor health outcomes, including cognitive impairment and Alzheimer disease. The presence and severity of white matter hyperintensities have traditionally been attributed to occlusive arteriopathy, but recent evidence also implicates deep medullary venule collagenosis and associated vasogenic edema. Historically, postmortem analyses have been the sole way to analyze cerebral veins, but SWI can be now used to examine cortical veins in vivo. The aim of the current study was to determine whether there is an association between the diameters of the large draining cerebral veins/sinuses and white matter hyperintensity volume.MATERIALS AND METHODS: T2-weighted FLAIR and SWI were performed in 682 older adults without dementia (mean age, 73.9 6 5.9 years; 59.1% women). Total and regional white matter hyperintensity volume was derived. We measured the diameters of 5 regions of the cerebral venous draining system: internal cerebral veins, basal veins of Rosenthal, superior sagittal sinus, vein of Galen, and straight sinus terminus. RESULTS:Increased diameter of the internal cerebral veins was associated with greater total white matter hyperintensity volume (b = 0.09, P = .02) and regionally in the parietal (b = 0.10, P = .006), frontal (b = 0.09, P = .02), and temporal (b = 0.09, P = .02) lobes. Increased diameter of the basal veins of Rosenthal was associated with greater total (b = 0.10, P = .01), frontal (b = 0.11, P = .003), and temporal (b = 0.09, P = .02) white matter hyperintensity volume. CONCLUSIONS:Our results suggest that the caliber of the internal cerebral veins and of the basal veins of Rosenthal relates to regional white matter disease. ABBREVIATIONS: AD¼ Alzheimer disease; WHICAP ¼ Washington Heights-Inwood Columbia Aging Project; WMH ¼ white matter hyperintensity; ICC ¼ intraclass correlation coefficient C hronic ischemia of the white matter of the brain can result in Indicates open access to non-subscribers at www.ajnr.org http://dx.

Background Small vessel cerebrovascular dysfunction that manifests on magnetic resonance imaging (MRI) as white matter hyperintensities (WMH) is linked to increased risk and progression of Alzheimer’s disease (AD), but there is considerable debate about whether it represents a core feature of the disease. Parental history of dementia is a risk factor for AD, suggesting a strong heritable component; the examination of the extent to which parental history of dementia is associated with cerebrovascular disease could provide insight into the aggregation of AD and cerebrovascular disease. Methods This study included 481 community-dwelling older adults (mean age = 74.07 ± 5.81; 56% women) with available MRI scans. Participants were classified as having a parental history of dementia or having no parental history based on self-report. Total WMH values were calculated and compared between the two groups with general linear models, adjusting for relevant covariates. We also compared WMH volume between those with a reported sibling history of dementia and those without. Results One hundred twelve participants reported having a parental history of dementia and 369 reported no parental history. Those with parental history had greater total WMH volume than those without (F = 4.17, p = .042, partial η 2 = 0.009). Results were strongest for those with maternal versus paternal history (F = 2.43, p = .089, partial η 2 = 0.010 vs <0.001) and among Hispanic (F = 5.57, p = .020, partial η 2 = 0.038) and non-Hispanic White participants (F = 4.17, p = .042, partial η 2 = 0.009). Those with reported sibling history of dementia did not differ from those without. Conclusions Older adults with parental, particularly maternal, history of dementia have increased WMH. The results highlight the possibility that cerebrovascular changes are a core feature of AD, as WMH severity and parental history aggregate together.

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