Objective To investigate the feasibility and complications associated with ceratohyoidectomy (CHE) in standing sedated horses unaffected (experimental horses) and standing sedated horses affected (clinical cases) with temporohyoid osteoarthropathy (THO). Study design Case series. Animals Six experimental horses and four clinical cases. Methods Standing CHE was performed in six experimental horses euthanized 30 minutes (n = 3) and 7 days (n = 3) postoperatively. The four clinical cases were presented because of central facial nerve paralysis (n = 3), vestibular ataxia (n = 3), auricular hemorrhage (n = 2), quidding (n = 1), and oesophageal impaction (n = 1). Evolution was assessed by clinical examination during hospitalization and later by telephone interviews for the clinical cases. Results The procedure was successfully performed in all horses. Experimental horses did not show any short‐term postoperative complications. Hemorrhage was experienced intraoperatively in one of the clinical cases and was successfully managed with placement of hemostatic forceps. Vestibular ataxia and other symptoms of THO improved within days, but facial nerve paralysis did not improve until 9 days to 6 months after surgery. Follow‐up ranged from 9 to 24 months. All clinical cases returned to performance, and client satisfaction was excellent. Conclusion Ceratohyoidectomy was consistently feasible in standing sedated horses. The method did not result in postoperative complications and led to resolution of clinical signs associated with THO. Clinical significance Standing CHE should be considered in horses affected with THO, especially when horses present with marked vestibular deficits and ataxia, to reduce risks associated with recovery from general anesthesia.
BackgroundRecurrent airway obstruction (RAO) is a severe chronic respiratory disease affecting horses worldwide, though mostly in the Northern hemisphere. Environmental as well as genetic factors strongly influence the course and prognosis of the disease. Research has been focused on characterization of immunologic factors contributing to inflammatory responses, on genetic linkage analysis, and, more recently, on proteomic analysis of airway secretions from affected horses. The goal of this study was to investigate the interactions between eight candidate genes previously identified in a genetic linkage study and proteins expressed in bronchoalveolar lavage fluid (BALF) collected from healthy and RAO-affected horses. The analysis was carried out with Ingenuity Pathway Analysis® bioinformatics software.ResultsThe gene with the greatest number of indirect interactions with the set of proteins identified is Interleukin 4 Receptor (IL-4R), whose protein has also been detected in BALF. Interleukin 21 receptor and chemokine (C-C motif) ligand 24 also showed a large number of interactions with the group of detected proteins. Protein products of other genes like that of SOCS5, revealed direct interactions with the IL-4R protein. The interacting proteins NOD2, RPS6KA5 and FOXP3 found in several pathways are reported regulators of the NFκB pathway.ConclusionsThe pathways generated with IL-4R highlight possible important intracellular signaling cascades implicating, for instance, NFκB. Furthermore, the proposed interaction between SOCS5 and IL-4R could explain how different genes can lead to identical clinical RAO phenotypes, as observed in two Swiss Warmblood half sibling families because these proteins interact upstream of an important cascade where they may act as a functional unit.
Summary A 10‐year‐old, 595 kg Irish Warmblood stallion used for showjumping was presented with a marked right forelimb lameness at walk. The horse sustained a dorsal plane fracture of the accessory carpal bone (ACB) when falling with both carpi in flexion. The fracture was repaired by means of computer‐assisted orthopaedic surgery (CAOS) using two cortex screws placed in lag fashion. In a second CAOS procedure, a dorsoproximal fragment of the ACB was removed after further proximal displacement had become apparent. Both surgical procedures were facilitated by the application of a fibreglass cast to immobilise the carpus in extension and to allow for the placement of the patient tracker distant from the surgical site. One year after surgery, the horse had returned to full athletic activity. Neither the antebrachiocarpal joint nor the carpal sheath were distended. Control radiographs and standing cone beam computed tomography showed complete osseous union of the fracture and osteophyte formation on the caudal aspect of the radius and the proximal border of the ACB.
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