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IMPORTANCEPremature death from all causes and cardiovascular disease (CVD) causes is higher among persons with diabetes.OBJECTIVE To investigate the association between time spent cycling and all-cause and CVD mortality among persons with diabetes, as well as to evaluate the association between change in time spent cycling and risk of all-cause and CVD mortality. DESIGN, SETTING, AND PARTICIPANTSThis prospective cohort study included 7459 adults with diabetes from the European Prospective Investigation into Cancer and Nutrition study. Questionnaires regarding medical history, sociodemographic, and lifestyle information were administered in 10 Western European countries from 1992 through 2000 (baseline examination) and at a second examination 5 years after baseline. A total of 5423 participants with diabetes completed both examinations. The final updated primary analysis was conducted on November 13, 2020.EXPOSURES The primary exposure was self-reported time spent cycling per week at the baseline examination. The secondary exposure was change in cycling status from baseline to the second examination. MAIN OUTCOMES AND MEASURESThe primary and secondary outcomes were all-cause and CVD mortality, respectively, adjusted for other physical activity modalities, diabetes duration, and sociodemographic and lifestyle factors. RESULTSOf the 7459 adults with diabetes included in the analysis, the mean (SD) age was 55.9 (7.7) years, and 3924 (52.6%) were female. During 110 944 person-years of follow-up, 1673 deaths from all causes were registered. Compared with the reference group of people who reported no cycling at baseline (0 min/wk), the multivariable-adjusted hazard ratios for all-cause mortality were 0.78 (95% CI, 0.61-0.99), 0.76 (95% CI, 0.65-0.88), 0.68 (95% CI, 0.57-0.82), and 0.76 (95% CI, 0.63-0.91) for cycling 1 to 59, 60 to 149, 150 to 299, and 300 or more min/wk, respectively. In an analysis of change in time spent cycling with 57 802 person-years of follow-up, a total of 975 deaths from all causes were recorded. Compared with people who reported no cycling at both examinations, the multivariable-adjusted hazard ratios for all-cause mortality were 0.90 (95% CI, 0.71-1.14) in those who cycled and then stopped, 0.65 (95% CI, 0.46-0.92) in initial noncyclists who started cycling, and 0.65 (95% CI, 0.53-0.80) for people who reported cycling at both examinations. Similar results were observed for CVD mortality. CONCLUSION AND RELEVANCEIn this cohort study, cycling was associated with lower all-cause and CVD mortality risk among people with diabetes independent of practicing other types of physical activity. Participants who took up cycling between the baseline and second examination had a considerably lower risk of both all-cause and CVD mortality compared with consistent noncyclists.

Objective: To study the association between organic food consumption and lifestyle, socio-demographics, and dietary habits. Design: Cohort participants completed detailed questionnaires about organic food consumption, diet, and lifestyle between 1999 and 2002. Polytomous logistic regression models were used to estimate the association between organic food consumption, and lifestyle, socio-demographics, and dietary habits. Setting: This cross-sectional study uses data from the Danish Diet, Cancer and Health cohort. Participants: A total of 43,209 men and women aged between 54 and 73 years were included in the study. Results: Overall, 15% reported never consuming organic food, 39% had low organic food consumption, 37% had medium organic food consumption and 10% had high organic food consumption. The relative risk of consuming organic food versus never consuming organic food was highest among women, persons with body mass index <25 kg/m2, persons with low alcohol intake, persons participating in sports, persons who did not smoke or were former smokers, and among persons who adhered to the Danish national dietary guidelines. Associations were more distinct with higher levels of organic food consumption. Conclusion: Based on a historical cohort of Danish adults, organic food consumption was associated with a generally healthy lifestyle, more favorable socio-demographics, and dietary habits. These findings have to be considered in the adjustment strategy for future studies linking organic food consumption with health outcomes.