INTRODUCTION Peak bone mass, which is the maximal bone mass accrued by an individual by the time it is reached the skeletal maturation, presents a determinant role in bone health throughout adulthood. It is attained between the end of the second and the beginning of the third decade of life, being 40 to 60% of its amount acquired during adolescence. Calcium is an essential mineral for bone formation. So, it is of paramount importance that adolescents and young adults meet their Dietary Reference Intake for calcium (DRI-Ca) to assure adequate bone mass acquisition. Several recent studies, both in our country and in a worldwide context, have shown that a significant proportion of individuals at those ages do not reach their DRI-Ca. AIM OF THE STUDY: Recognize the calcium dietary intake (Ca-DI) among a small sample sized group of teenagers and young adults in Brasilia, Brazil, and compare the obtained data with the recommended DRI-Ca according to the specific age group. It corresponds to the preliminary branch of a more robust ongoing study. PATIENTS AND METHODS Cross sectional pilot study carried out with 15 to 18-year-old adolescents and 19 to 23-year-old young adults attending a university health fair. It was used a validated questionnaire and Ca-DI was determined using the International Osteoporosis Foundation calculator. The obtained data was compared to the DRI-Ca according to the age range: 1,300 mg/day for the adolescent group and 1,000 mg/day for young adults (Institute of Medicine, USA) . RESULTS Thirty-four individuals were included (20 females). Mean age was 18.9 ± 2 yr. Sixteen individuals (12 females) were in the adolescent group and 18 (8 females) in the young adult one. Average Ca-DI for both groups were below their respective DRI-Ca. Mean Ca-DI was 751.8 ± 384 mg/day (57.8 ± 29.5% of DRI-Ca) in the adolescent group, with no difference between sexes (p = 0.22). In the young adult group mean Ca-DI was 792.8 ± 346.6 mg/day (79.3 ± 34.7% of DRI-Ca). In the latter group female individuals showed significantly lower (615.5 ± 131.2 mg) Ca-DI when compared to males (934.6 ± 404 mg), p = 0.038. There was no statistical difference when comparing both age groups regarding their reached percentage of DRI-Ca (p = 0.06). CONCLUSION Although these results were based on a small preliminary cross-sectional study, they may signalize a real warning concerning low Ca dietary intake among adolescents and young adults in our population, especially by the female young adult group.
INTRODUCTION: Thyroid carcinoma is the most common endocrine neoplasia. The predominant histological variant is the papillary subtype. Tumors with 1 centimeter diameter or less are defined as papillary thyroid microcarcinoma (PTMC). The clinical diagnosis of PTMC is challenging. The evaluation of the gland includes mostly image methods and fine-needle aspiration (FNA). Nevertheless, the sensibility of these techniques, when compared to total thyroid histology, is less than desired. AIM OF THE STUDY: Recognize the real prevalence of papillary thyroid microcarcinoma (PTMC) based on histological evaluation of the total gland among a group of adults in Brasilia, Brazil, and compare the data with the clinical suspicion of PTMC established by FNA and ultrasonography (USG). PATIENTS AND METHODS: Retrospective cohort study based on medical records of 76 patients who underwent surgical thyroidectomy treatment for several types of thyroid diseases at the University Hospital of Brasilia - Brazil, from 2005 to 2015. A full inclusion of the surgical specimen was made and stained with hematoxylin and eosin. All of the preparations were evaluated by an expert pathologist. The histopathological report was compared to the previous clinical diagnosis, which was based on FNA and USG of the gland. In addition, the exams results were stratified by the Bethesda criteria. RESULTS: Seventy-six individuals with the histopathology diagnosis of PTMC were included (68 were females). A total of 65 FNA and 57 USG results were evaluated, 6 patients had only the histopathologic diagnosis of PTMC. A total of 52 patients had both USG and FNA of the thyroid. All of the patients that had USG records had at least one thyroid nodule, 52,6% of them had multiple nodules. Regarding the FNA results, only 9,2% were classified as Bethesda I; 21,5% as Bethesda II; 7,7% Bethesda III; 7,7% Bethesda IV; 10,8% Bethesda V; 43,1% Bethesda VI. At this cohort, 19 patients were false negatives. The sensibility of FNA for diagnosis of PTMC was 67,79%. CONCLUSION: Despite careful evaluation of the patients, there might have false negatives results. Total thyroid total inclusion of surgical specimen is not a routine diagnostic tool, making less invasive new diagnosis methods desirable.
INTRODUCTION: The thyroid papillary microcarcinoma (TPMC) is defined as a tumor ≤ 1 centimeter. This variant of thyroid papillary carcinoma is generally characterized by slow progression and minimal invasion. Although the TPMC subtype usually has good prognosis, itʼs early recognition has clinical relevance because it may present with regional lymph node metastasis, as well as increased risk of recurrence. AIM OF THE STUDY: The aim of the study is to identify the epidemiologic profile of the population diagnosed with TPMC, as well as the signs and symptoms observed in these patients. This study intends to guide early clinical suspicion of thyroid tumors; in order to propose assertive forms of management and prevention of undesirable outcomes. PATIENTS AND METHODS: Retrospective cohort study based on medical records of patients diagnosed with TPMC at University Hospital of Brasilia-Brasil, from 1999 to 2017. The clinical aspects analysed were: gender; race; age of the patient when the diagnosis was made; symptoms reported by the patients regarding the pathology and comorbidities. RESULTS: Fifty-eight patients who underwent thyroidectomy for variable thyroid criteria were included in this study. 87,93% were women, (seven fold higher female prevalence of the TPMC). Mean age of diagnosis was 42, 94 ± 11,4. Regarding the race, the majority of the patients had self-entitled as mixed race, which corresponds to 39,65% of the sample. Symptoms reported included dysphagia (29,31%), dyspnea (17,24%) and feeling of neck compression (13,79%). Even though these aspects of the clinical approach are significant diagnosis tools, only 26,5% of the patients in this sample attested those kinds of signs/symptoms. Considering that actual clinical manifestation is relatively rare, total inclusion of the anatomic specimen is useful in this unsettling scenarios. Among the most commonly reported comorbidities, benign thyroid affections were the most prominent, such as multinodular goiter and hypothyroidism. CONCLUSION: Analysis of the data endorses that the TPMC does not have a well defined clinic presentation. Nonetheless, dysphagia is the most reported symptom. Analysis of the data pointed to a higher prevalence of the pathology in women in their 40s, which can be used as parameter of investigation on patients that have symptoms that cannot be explained by other pathologies. Although TPMC usually presents with good prognosis, the non incidental groups may present with aggressive behavior and should be treated as papillary thyroid carcinoma. Despite that, fine needle aspiration and ultrassonografy are the preferable methods in the evaluation of thyroid tumors.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.