At least 20 genes encode the structurally related collagen chains that comprise >10 homo-or heterotrimeric types. Six members of this multigene family have been assigned to five chromosomes in the human genome. The two type I genes, al and a2, are located on chromosomes 17 and 7, respectively, and the al(ll) gene is located on chromosome 12. Our recent mapping of the al(llI) and a2(V) genes to the q24.3-*q31 region of chromosome 2 provided the only evidence that the collagen genes are not entirely dispersed. To further determine their organization, we and others localized the al(IV) gene to chromosome 13 and in our experiments sublocalized the gene to band q34 by in situ hybridization. Here we show the presence of the ci2 type IV locus also on the distal long arm of chromosome 13 by hybridizing a human a2(IV) cDNA clone to rodent-human hybrids and to metaphase chromosomes. To our knowledge, these studies represent the only demonstration of linkage between genes encoding both polypeptide chains of the same collagen type.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.