Human anisakiasis is a parasitosis caused by the accidental ingestion of the infecting larvae of nematodes of the Anisakidae family, mainly Anisakis simplex and Pseudoterranova decipiens. Infection is acquired from the consumption of fish, such as, salmon, codfish, herring, silver hake, flounder and squid 1 . When the fish is improperly cooked, frozen or irradiated, infection is possible.In Japan, anisakiasis is frequent, due to the consumption of sushis and sashimis. It is also common in Holland, Scandinavia and along the Pacific coast of Latin America. In Brazil, there are no reports of this human infection, although studies have shown the existence of some contaminated fish. Dorado, anchovies, red porgy and swordfish have been cited, especially from the northeast region. Moreover, it is known that Anisakis physeteris and Pseudoterranova sp. have been found in the stomachs of Kogia breviceps whales, in Brazil, off the coast of Fernando de Noronha, indicating a new geographic distribution of this parasite The disease has two distinguishing characteristics: 1) the local effect of the parasite on the digestive tract and 2) allergy, due to immediate hypersensitivity from the immunoglobulin E. The former generally occurs from a single larva in the digestive tract, which provokes local irritation with symptoms, such as nausea, vomiting, and epigastric pain. There are occasional reports of disturbances such as appendicitis, peritonitis and even Crohn's disease. In cases of severe pain, surgery to remove the nematode is required. The latter characteristic, allergy, is caused by the parasites' antigens, occasionally resulting in clinical pictures that can vary from simple urticaria to angioedema, including anaphylactic shock 5,6 . We attended three patients that were probably infected with anisakiasis. Diagnosis was based on clinical aspects, laboratorial alterations and epidemiological circumstances that can be important in the acquisition of the helminthiasis. Relevant clinical data are as follows: VMA, 43 years old, pain in several parts of the body, for the last seven days at the time of reporting; eosinophilia (32% -664/mm³ and soon after 38% -5,940/ mm³); CAIS, 38 years old, abdominal pain for two days; macular rash in the body trunk; eosinophilia (25% -3475/mm³ and soon after 38% -4,902); ACA, 28 years old, epigastric pain for ten days; macular rash in the abdomen; eosinophilia (20% -2,200/mm³).One of the patients was treated with albendazol, based on the elevated eosinophilia. Adequate treatment is not known for human anisakiasis, and benefits from the aforementioned anti-helminthic medicine are unknown.Clinical evidence of the three patients and the hematological alterations suggest a diagnosis of anisakiasis.Nine persons from São Paulo City, (São Paulo State, Brazil), traveled to Ilha do Bananal, Tocantins State, Brazil, to fish. Five of these persons that ate raw fish of the genus Cichlydae became sick and three were attended at a medical service. They did not receive an adequate in-depth clinico-laboratoria...