13 Resumo Objetivo: Conhecer o perfil dos usuários atendidos na sala vermelha de um Hospital Universitário de Pernambuco. Métodos: Estudo descritivo, exploratório e quantitativo, realizado no setor do atendimento de emergência de um Hospital Universitário de Pernambuco, utilizando como fonte de dados o Livro de Registro dos atendimentos diários, coletados de janeiro a junho de 2013. Os dados foram organizados em uma planilha no programa Microsoft Office Excel ® 2010. Logo após, foram apresentados em gráfico e tabelas, confrontando os resultados com a literatura. Resultados: A maioria dos pacientes atendidos é do sexo masculino, entre 20 e 29 anos, procedentes da mesma cidade, onde está localizado o hospital, e vítimas de causas externas, principalmente acidentes motociclísticos. Conclusões: A população economicamente ativa foi a mais atingida pelas causas externas, o que pode desencadear despesas elevadas para o Sistema Único de Saúde (SUS). Espera-se que o estudo sirva de subsídio para implantações de políticas públicas municipais e regionais. Palavras-chave: Serviços médicos de emergência. Causas externas. Sistema Único de Saúde. ARTIGO ORIGINAL DE TEMA LIVRE PERFIL DOS USUÁRIOS ATENDIDOS NO SERVIÇO Abstract Objective: To be aware of the profile of the patients cared in the emergency room of the University Hospital of Pernambuco. Methods: DA descriptive, exploratory and quantitative study. We carried out this research in the emergency room of the University Hospital of Pernambuco, usinged as a source the visitor registration book, with datacollected collected from January to June 2013 sector. The selected variables were organizedin a Microsoft Office Excel 2010 spreadsheet in Microsoft Office Excel 2010 program. Shortly after, those data were presented in graphic and tables comparing the results with the literature. Results: The majority of cared patients seen is male, ranging from 20 to 29 years old, coming from the same city where the hospital is located, and victims of external causes, especially motorcycle accidents. Conclusions: The economically active population was the most affected by external causes, which may triggering higher costs for the Unified HealthSystem (SUS). We hoped that this study will serves as an input for the implementation deployments of municipal and regional health public policiesy.
Objetivo: Conhecer o perfil dos usuários atendidos na sala vermelha deum Hospital Universitário de Pernambuco. Métodos: Estudo descritivo, exploratórioe quantitativo, realizado no setor do atendimento de emergência de um HospitalUniversitário de Pernambuco, utilizando como fonte de dados o Livro de Registro dosatendimentos diários, coletados de janeiro a junho de 2013. Os dados foram organizadosem uma planilha no programa Microsoft Office Excel® 2010. Logo após, foram apresentadosem gráfico e tabelas, confrontando os resultados com a literatura. Resultados: A maioriados pacientes atendidos é do sexo masculino, entre 20 e 29 anos, procedentes da mesmacidade, onde está localizado o hospital, e vítimas de causas externas, principalmenteacidentes motociclísticos. Conclusões: A população economicamente ativa foi a maisatingida pelas causas externas, o que pode desencadear despesas elevadas para o SistemaÚnico de Saúde (SUS). Espera-se que o estudo sirva de subsídio para implantações depolíticas públicas municipais e regionais.
PURPOSE:To investigate the induction of neoplastic lesions under the action of ultraviolet B radiation (UVR-B) and dimethyl benzanthracene (DMBA). METHODS:Forty Wistar rats were assigned to four groups (ten animals each), according to the procedure: group A received UVR-B irradiation, group B received topic DMBA, group C, UVR-B+DMBA and group D as control, observed for ten weeks. In the tenth week they went through a skin biopsy and histopathological study. The average thickness of the epidermis was calculated and evaluated statistically. RESULTS:Macroscopic lesions in group B were more of inflammatory kind compared to group A. Group C presented more injuries with neoplastic features than the others (p<0.01). Histologically there was a significant increase in thickness of the epidermis of all groups compared to control, however the greatest thickness measures occurred in Group C (p<0.01). CONCLUSIONS:The population exposed to ultraviolet B radiation is subject to suffer skin lesions that can develop into cancer. The association with hydrocarbons as the dimethyl benzanthracene increases the possibility of malignancy. May not be clinically evident determine when a solar keratosis ends and when a CEC begins. For this reason, histological study associated with health education prompting the early and irreversible injury prevention is necessary.
Background/Aim: The pesticide dimethoate (O-dimethyl-S-Nmethylcarbamoylmethyl phosphorodithioate) is able to induce severe acute toxicity in living organisms. The aim of this study was to evaluate the effects of ultraviolet radiation, alone or combined with exposure to dimethoate, on the rat skin. Materials and Methods: A total of 38 Wistar female rats (Rattus norvegicus albinus), were distributed into four groups: A (n=9) control group, B (n=10) exposed to ultraviolet-B radiation (UV-B), C (n=10) exposed to UV-B followed by application of dimethoate (UV-B+AGRO) and group D (n=9) exposed to dimethoate (AGRO). Histological examination of the tissues, as well as immunohistochemistry for cleaved caspase 3, Ki-67 and COX-2 expression were performed to all groups. Results: Animals submitted to UV-B exhibited hyperkeratosis with moderate cell atypia. Regarding exposure to UV-B+AGRO, the animals presented hyperkeratosis and atrophy, whereas in animals exposed to AGRO, only atrophy was noticed. The immunohistochemical results on skin revealed that UVB, AGRO and UVB+AGRO decreased cleaved caspase 3 and Ki-67 expression when compared to the control group (p<0. 05). COX-2 expression decreased to UVB or AGRO groups compared to controls (p<0.05). Conclusion: UV-B or AGRO exposure is able to induce histopathological changes and altered expression of cleaved caspase-3 and Ki-67 in rat skin, thus being categorized as a risk condition for skin carcinogenesis.According to the International Agency for Research on Cancer (IARC), occupational exposure is the main form of human contact with carcinogens, such as pesticides and ultraviolet (UV) radiation (1). Work-related neoplasms are found in some organs, such as skin, lungs, stomach and bladder, among others, being directly absorbed or even eliminated from various carcinogenic agents (2).The National Cancer Institute in Brazil estimated in 2016 about 596,000 new cases of cancer, of which non-melanoma skin cancer is the most common (180,000). This is the most frequent type of human cancer and shows an increase in its incidence in recent years, becoming a growing public health problem worldwide (3). On the other hand, melanoma skin cancer has a high lethality, but its incidence is low, affecting 5,670 new cases annually (3).Occupational exposure to UV radiation is a known risk factor for skin cancer (4). The action of UV radiation on the skin is a complex process that is associated with chemical and morphological changes, such as formation of reactive oxygen species, histochemical changes of different severities, thickening of the prickly layer and rectification of the basal layer of the epidermis. It also activates components of the cutaneous immune system and the release of inflammatory mediators by direct activation of keratinocytes and suppression of Langhans cells (5). DNA is one of the major molecules that absorbs UV radiation and undergoes several mutations that can subsequently result in malignant transformations of the eukaryotic cell (6). It has been demonstrated that continu...
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