Background: Not every T helper type 2 (Th2) lymphocyte imprinted to express interleukin-4 (IL-4) does so when activated.Results: Preventing nuclear translocation of the nuclear factor of activated T cells (NFAT) reduces the number of Th2 lymphocytes reexpressing IL-4.Conclusion: NFAT is the limiting factor determining digital IL-4 expression in Th2 lymphocytes.Significance: This might help us to understand the regulation of immunopathology in allergy and asthma.
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