As part of the GENACIS project, this paper sought to assess the prevalence of depression in an urban sample in the city of São Paulo, Brazil, as well as the association between depression and alcohol abuse according to gender. To achieve this, an epidemiological survey was conducted using a stratified probability sample, including 2,083 adults. CIDI SF was used to identify depression. The Rao Scott test and multivariate logistic regression were used for statistical analysis. The response rate was 74.9%. Females (58.3%) under 40 years of age (52%) were predominant. The prevalence of depression was 28.3% for women and 12.7% for men. Most men declared being drinkers (61.1%) in the last year. Depression was associated with an alcohol drinking pattern, mostly binge drinking, in addition to the occurrence of problems derived from alcohol use. Most women declared being abstainers (69.5%). Depression was associated with cohabiting with spouses with alcohol-related problems. Results reveal that the association between depression and alcohol consumption is distinct between genders.

RESUMO Objetivos: O transtorno depressivo maior (TDM) é muito prevalente e incapacitante, sendo comum a persistência de prejuízos funcionais após a remissão clínica. Pesquisas que se proponham a estudar a reabilitação em TDM são necessárias. Há carência de instrumentos que avaliem a funcionalidade em sujeitos com TDM. Objetiva-se observar as propriedades psicométricas da escala FAST em amostra brasileira, casos (n = 44) e não casos (n = 44) de TDM. Métodos: a) Questionários com informações socioeconômicas e escala Mini International Neuropsychiatric Interview 5.0.0 para rastrear em sala de espera de serviços ambulatoriais de duas universidades públicas do Estado de São Paulo; b) entrevistas face a face com os instrumentos FAST, Avaliação Global de Funcionamento e Escala de Hamilton para Depressão. Resultados: Houve fortes correlações entre FAST e AGF (rho = −0,85) e entre cada subescala e a escala total (rho = 0,86), boa consistência interna (alfa de Cronbach 0,98) e confiabilidade teste-reteste (Kappa ponderado >0,84). O estudo de validade discriminativa evidenciou que a FAST discrimina os casos de não casos de TDM, assim como moderados/graves dos demais. Conclusão: As propriedades psicométricas da FAST em 88 sujeitos mostraram boa confiabilidade e validade para aferir o impacto da depressão na funcionalidade em brasileiros com TDM. Recomendam-se estudos futuros com amostras maiores.

Background: Major Depressive Disorder (MDD) has been shown a high prevalence and debilitating mental health. Most of the burden comes from reduced work functioning and frequent or long-term absenteeism. Aims: Describe psychosocial functionality in sample of workers with MDD and observe associated factors with sick-leave. Methods: Cross-sectional study. Participants were 172 formal workers with MDD according to Mini International Neuropsychiatric Interview. They were classified as active ( n = 76) or in sick leave ( n = 96). Functionality Assessment Short Test (FAST) was used and the variables were: personal, clinical, and occupational characteristics. Descriptive, bivariate and hierarchical multivariate analyses were conducted; significant with p < .05. Results: Most of the sample was female and <50. Workers in sick leave were older, less physically active, and presented worse scores in global and in each domain of functionality (FAST). High autonomy at working process, perceived stressing work, do not enjoy the work and low resilience to work adversities were significantly associated with sick leave ( p < .05). Regarding clinical characteristics of MDD, severity, clinical comorbidity and recidivate subtype were associated with sick leave outcome ( p < .05). Conclusion: Sick leave is an important indicator of global functionality. Effective strategies to reduce MDD burden ought to involve some perspectives: (1) Diagnosis and efficient treatment; (2) Promotion and monitoring of functionality and rehabilitation programs; (3) Subject-centered actions that help workers cope with adversities, mitigate stress, and increase satisfaction at work.

DedicatóriaAos meus pais, por me darem o exemplo de resistência e perseverança. A Giovanni, Antonio e Ana, pela inspiração, cuidado e paciência, mil vezes. RESUMO PRADO, J. A. Depressão e absenteísmo-doença: estudo dos fatores associados em amostra de trabalhadores de uma universidade pública do Estado de São Paulo. 2018. 156 f. Tese (Doutorado) -Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 2018. com adversidades se mostrou fator de proteção para o desfecho. Observa-se a complexidade das relações entre os determinantes e o desfecho apontando que as estratégias de intervenção devem ser multidisciplinares e intersetoriais. Palavras-chave: Depressão. Absenteísmo-doença. Ocupacional. Fatores associados. ABSTRACT PRADO, J. A. Major Depressive Disorder and absenteeism: study of factors associated with in sample of workers of a public university in São Paulo, Brazil, 2018. 154 fls. Thesis (Doctorate) -Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 2018.Major Depressive Disorder (MDD) is a health condition very prevalent in the general population and of workers and is associated with great socioeconomic impact, mainly at the expense of functional disability and falling productivity. WHO data indicate depression as the main cause of YLD in the world. In Brazil, is the third cause of granting the benefits of INSS, both of which have increased estimates for the next decade. The changes that have been taking place in the world of work, since the mid-twentieth century, can be linked the increased prevalence of absenteeism for depression, mainly at the expense of workers exposure to psychosocial factors more in adverse and greater demand for skills and mental resources by the labour market. So, think action strategies on occupational health that modify the high rates of illness and departure from work passes, necessarily, to meet the factors associated with these outcomes. The literature provides data on the determinants, but there are no records held in the national territory. The aim of this study was to observe the factors that associate with the absenteeism in subjects with MDD in sample of formal workers of a public university in São Paulo, Brazil. It is a cross-sectional study in convenience sample of selected workers in specialized social assistance and occupational health of the university. Totaled if 172 workers diagnosed with MDD from M.I.N.I. that were divided into two groups: active at work (N76) and in absenteeism (N=96). The data collection was made by using face-to-face interview for application of the questionnaire developed for this study. The sample was characterized from the socioeconomic data, habits and lifestyle, functionality from FAST scale, conditions and psychosocial factors at work, clinical characteristics and personality. The comparison between the groups was performed by means of bivariate analyses by Fisher´s test and the study of factor associated with absenteeism was made by means of multivariate logistic regression, hi...