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In the present study the extract of the secondary metabolites (E-G6-32) produced by the Curvularia sp. G6-32 endophyte (isolated from the medicinal plant Sapindus saponaria L.) and its biological activities were investigated. The antioxidant potential was confirmed by the DPPH (22.5%) and ABTS (62.7%) assays; the total phenolic compound content was 40 µg gallic acid equivalents/mg. The extract E-G6-32 displayed good inhibitory activity toward butyrylcholinesterase (BuChE; IC 50 = 110 ± 0.05 µg mL -1 ). The extract E-G6-32 was subjected to spectroscopic and mass spectrometry analyses ( 1 H and 13 C NMR, HMBC, HSQC, COSY, and MS/MS). Comparison with the literature data confirmed that (-)-asperpentyn (1) was a major component. Asperpentyn belongs to the epoxyquinone family that has attractive structural complexity, diverse functional groups, and a broad range of biological activities, including specific enzyme inhibitory activity. Our results suggest that Curvularia sp. G6-32 is a promising source of bioactive secondary metabolites that contain (-)-asperpentyn, which has potential pharmaceutical interest.

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