Sepsis is a severe disease with a high mortality index and it is responsible for the development of acute lung injury (ALI). We evaluated the effects of light-emitting diode (LED) on ALI induced by sepsis. Balb-c mice were injected with lipopolysaccharide or saline and then irradiated or not with red LED on their tracheas and lungs for 150 s, 2 and 6 h after LPS injections. The parameters were investigated 24 h after the LPS injections. Red LED treatment reduced neutrophil influx and the levels of interleukins 1β, 17 A and, tumor necrosis factor-α; in addition to enhanced levels of interferon γ in the bronchoalveolar fluid. Moreover, red LED treatment enhanced the RNAm levels of IL-10 and IFN-γ. It also partially reduced the elevated oxidative burst and enhanced apoptosis, but it did not alter the translocation of nuclear factor κB, the expression of toll-like receptor 4 (TLR4), as well as, oedema or mucus production in their lung tissues. Together, our data has shown the beneficial effects of short treatment with LED on ALI that are caused by gram negative bacterial infections. It is suggested that LED applications are an inexpensive and non-invasive additional treatment for sepsis.

CONTEXT AND OBJECTIVE: Hemangiomas are the commonest vascular tumors during childhood. In 2008, the effect of propranolol for treating capillary hemangiomas was demonstrated. Other similar results followed, showing that it rapidly reduces lesion volume. The objective here was to evaluate children and adolescents with hemangiomas that were treated with propranolol. DESIGN AND SETTING: Retrospective study, conducted in a children's hospital. METHODS: Patients aged 0-19 years with or without previous treatment, who were treated between January 2009 and December 2010, were included. The response was assessed by comparing the lesion appearance between the start of treatment and the last consultation. We considered partial or complete responses as the response to treatment. RESULTS: Sixty-nine patients with a median follow-up of 11 months (mean age: 31 months) were included. Of these, 58 patients were recently diagnosed and 11 had had previous treatment. A response (partial or complete) was seen in 60 patients (87%). Among the capillary hemangioma cases, responses were seen in 50 out of 53 (94%), while in other lesion types, it was 10 out of 16 (63%) (P = 0.3; chi-square).Responses in patients less than one year of age were seen in 37 out of 38 (97%), whereas in those over one year of age, in 23 out of 31 (74%) (P = 0.4; chi-square). Side effects were uncommon and mild. CONCLUSIONS: Propranolol seemed to be effective for treatment of hemangiomas in children and adolescents, and not just in the proliferative stage, with responses in almost all the patients. Resposta (parcial ou completa) foi verificada em 60 pacientes (87%). Entre os hemangiomas capilares, a resposta foi de 50 em 53 (94%), enquanto em outros tipos de lesões, a resposta foi de 10 em 16 (63%) (P = 0,3; teste de qui-quadrado). A resposta em pacientes com até 1 ano de idade foi de 37 em 38 (97%), e naqueles com mais de 1 ano foi de 23 em 31 (74%) (P = 0,4; qui-quadrado). Efeitos colaterais foram incomuns e leves. CONCLUSÕES: Propranolol parece ser efetivo no tratamento de hemangiomas em crianças e adolescentes, não apenas na fase proliferativa, com resposta em quase todos os pacientes. RESUMO

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As neoplasias hepatobiliares primárias são raras em gatos. Elas podem se diferenciar de acordo com a sua forma de expansão em nodular, maciço ou difuso. O diagnóstico definitivo é com exame histopatológico. No entanto, em sua maioria, o diagnóstico acaba por ser no post mortem. Devido ao seu comportamento biológico agressivo, o prognóstico torna-se desfavorável. O objetivo do presente trabalho foi relatar o caso de uma fêmea felina de nove anos de idade com doença renal crônica e portadora do vírus da leucemia felina, que foi diagnosticada com colangiocarcinoma primário de evolução rápida (30 dias) que evoluiu para metástase em duodeno e baço.

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