We analyzed and quantified the 100 most frequently cited papers in macular imaging using optical coherence tomography (OCT). The databases of the Institute for Scientific Information databases utilized for identification of articles in macular imaging using OCT over the last 25 years since the introduction of OCT in ophthalmology. All articles containing "optical coherence tomography" and "retina" without "glaucoma". The publication dates of the 100 most-cited articles ranged from 1991 to 2015, with the greatest number of articles published in the 2000s, while the total number of citations per article was greatest for articles published in the 1990s. Most studies were conducted in the U.S. and represented Level-IV clinical outcome studies indicating that also small case series or cohort studies could gain attention. The top 5 senior authors contributed to 39 of the 100 selected publications and accrued a total of 66.0% of all citations of those articles.
Background/Aims To investigate a possible association between the use of hydrochlorothiazide (HCT) and/or angiotensin-converting enzyme inhibitors (ACE inhibitors) and the occurrence of periocular non-melanoma skin cancer. Methods The files of 929 patients from the University Medical Center Hamburg-Eppendorf who were surgically treated for suspected periocular malignancy were evaluated retrospectively regarding the occurrence of non-melanoma skin cancer and concomitant medication. To be able to put the data in an overall context, we also analyzed age-matched routine data of the DAK-Gesundheit (DAK-G), a nationwide operating German health insurance company. Results Of the 929 patient records examined, who underwent surgical excision for suspected non-melanotic malignancy, non-melanocytic skin cancer could actually be determined by histology in 199 patients. In total, 176 patients (103 women, 72 men) had a basal cell carcinoma and 23 patients (16 women, 7 men) suffered from squamous cell carcinoma. The rate of intake of HCT or ACE inhibitors in our patient collective with non-melanotic skin cancer is significantly higher than in the general age-matched population (ORACE: 2.51, p < 0.001; ORHCT: 7.24, p < 0.001, ORBOTH: 4.61, p < 0.001). Conclusion The rate of intake of HCT or ACE inhibitors is significantly higher in our patient collective with non-melanotic skin cancer compared to the group from the age-matched general population (DAK insured (p < 0.001)) compared to the routine data of the DAK-G. This leads us to the conclusion that taking the medication is associated with an increased risk for non-melanotic skin cancer. We recommend regular skin cancer screening, moderate ordination of photosensitizing medication, but above all comprehensive clarification of possible risks.
Bibliometric science employs statistical and quantitative analyses to analyse the scholarly impact and characteristics of publications within a research field. The present study was initiated to analyse and quantify the 100 most often cited papers in glaucoma research. The databases of the Institute for Scientific Information were utilised for the identification of articles published from 1900 to December 2016. All glaucoma articles were identified that had been published in 109 relevant journals and which had been cited at least 200 times. The top 100 articles were selected for further analysis of authorship, source journal, number of citations, citation rate, geographic origin, article type, and level of evidence. The publication dates of the 100 most often cited articles ranged from 1966 to 2011, with the greatest number of articles published in the 1990s. Citations per article ranged from 258 to 1908. All articles were published in 18 of the 109 journals. The leading countries of origin were the U. S. A., followed by the U. K. The study focussed on two main clinical articles (diagnostics; epidemiology) and basic research articles. The number of citations per article was greatest for articles published in the 2000s. Most articles provided level III evidence, followed by levels I and II. The majority of the most cited articles were published in three of the top-ranked journals. Most clinical articles dealt with epidemiology and diagnostics. Individuals who authored multiple articles in the list often focussed on one of these two areas. Most studies were conducted in the U. S. A. and presented level III clinical outcomes. This indicates that even studies with small case series or cohort studies can attract attention.
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