Tobacco and alcohol are often co-abused. Nicotine can enhance alcoholic fatty liver, and CYP2A6 (CYP2A5 in mice), a major metabolism enzyme for nicotine, can be induced by alcohol. CYP2A5 knockout (cyp2a5) mice and their littermates (cyp2a5) were used to test whether CYP2A5 has an effect on nicotine-enhanced alcoholic fatty liver. The results showed that alcoholic fatty liver was enhanced by nicotine in cyp2a5 mice but not in the cyp2a5 mice. Combination of ethanol and nicotine increased serum triglyceride in cyp2a5 mice but not in the cyp2a5 mice. Cotinine, a major metabolite of nicotine, also enhanced alcoholic fatty liver, which was also observed in cyp2a5 mice but not in the cyp2a5 mice. Nitrotyrosine and malondialdehyde (MDA), markers of oxidative/nitrosative stress, were induced by alcohol and were further increased by nicotine and cotinine in cyp2a5 mice but not in the cyp2a5 mice. Reactive oxygen species (ROS) production during microsomal metabolism of nicotine and cotinine was increased in microsomes from cyp2a5 mice but not in microsomes from cyp2a5 mice. These results suggest that nicotine enhances alcoholic fatty liver in a CYP2A5-dependent manner, which is related to ROS produced during the process of CYP2A5-dependent nicotine metabolism.
Cancer patients often
use cannabinoids for alleviating symptoms
induced by cancer pathogenesis and cancer treatment. This use of cannabinoids
can have unexpected effects in cancer patients depending on the cancer
type, resulting in either beneficial (e.g., anticancer) or adverse
(e.g., oncogenic) effects. While cannabinoids can enhance the growth
and progression of some cancers, they can also suppress the growth
and progression of other cancers. However, the underlying mechanisms
of such differential effects are poorly understood. miRNAs have been
shown to be involved in driving the hallmarks of cancer, affecting
cancer growth and progression as well as cancer therapy response.
Although the understanding of the effects of cannabinoids and miRNAs
as they relate to cancer continues to improve, the interplay between
cannabinoid system and miRNAs in cancer pathogenesis and cancer treatment
response is poorly understood. Investigation of such interactions
between the cannabinoid system and miRNAs could provide novel insights
into the underlying mechanisms of the differential effects of cannabinoids
in cancer and can help predict and improve the prognosis of cancer
patients.
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