Our results show that the intermediate filament protein nestin regulates the early stages of myogenesis by a bidirectional interrelationship between nestin and Cdk5. Cdk5 regulates the organization and stability of its own scaffold nestin, which in turn controls the effects of Cdk5.

CDK5 acts as a signaling hub in prostate cancer cells by controlling androgen responses through AR stabilization and specific gene targeting, maintaining and accelerating cell proliferation through activation of the oncogenic AKT kinase, and releasing cell cycle breaks in a variety of prostate cancer cell lines.