Working from dynamic, strategic, and collective qualities of activity to discussion of the concept of "Script" in sociological and anthropological literature, this article further develops the idea of the "ethnic script." We consider the ethnic script to be an interpretative framework, tightly connected to group identity and to designing actions of ethnic group members with respect to sociocultural institutions and other social groups within a given society. Our proposition is that migration problematizes the affinity among script, place, and identity. As a result research on immigration allows us to deepen understanding of both the analytical notion of "Script" and the processes of identity construction in migration. The case study of Russian Jewish immigrants in Israel is used to examine empirically how these migrants activate their ethnic script in their struggle for place and identity. This script prescribes acquiring higher education as a means to belonging in the "intelligentsia" and fulfilling Jewishness. The ethnic nature of the examined script exposes its strategic role in the power relations involved in the migration process. The article shows how immigrants mobilize and maneuver the script as a flexible interpretative strategy for relocation within the hierarchical social structure of the receiving society.
Angiogenesis is largely driven by motile endothelial tip-cells capable of invading avascular tissue domains and enabling new vessel formation. Highly responsive to Vascular Endothelial Growth-Factor-A (VEGFA), endothelial tip-cells also suppress angiogenic sprouting in adjacent stalk cells, and thus have been a primary therapeutic focus in addressing neovascular pathologies. Surprisingly, however, there remains a paucity of specific endothelial tip-cell markers. Here, we employ transcriptional profiling and a lacZ reporter allele to identify Kcne3 as an early and selective endothelial tip-cell marker in multiple angiogenic contexts. In development, Kcne3 expression initiates during early phases of angiogenesis (E9) and remains specific to endothelial tip-cells, often adjacent to regions expressing VEGFA. Consistently, Kcne3 activation is highly responsive to exogenous VEGFA but maintains tip-cell specificity throughout normal retinal angiogenesis. We also demonstrate endothelial tip-cell selectivity of Kcne3 in several injury and tumor models. Together, our data show that Kcne3 is a unique marker of sprouting angiogenic tip-cells and offers new opportunities for investigating and targeting this cell type.
In this article we present a close reading of the discursive media transformation generated by “Fashion Verdict”—a makeover reality show broadcast on Russian TV. Our analysis reveals that the adopted genre of therapeutic culture constitutes a new mode of talk about personal experience in the post-Soviet media, a mode based on pop-psychological assumptions and linked to the discursive practice of psychotherapy. However, we show that in post-Soviet popular culture the global therapeutic talking culture encounters powerful cultural counterparts. Apart from psychotherapy, the TV courtroom transformation works by shifting three other discursive frames of articulation of individual and personal life: communist Comrades' Court, soviet Kitchen Talk, and glamorous Fashion Show. Combining an anthropological approach with conversational and frame analysis, we decipher how the familiar discursive forms of talking about personal life domesticate the therapeutic discourse in the Russian communicative culture: they pave the way for its acceptance and concomitantly contest and possibly undermine the ideas that the therapeutic culture brings in.
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