Julia Jun Li scite author profile

Julia Jun Li

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Chinese University of Hong Kong

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MYC Protein Inhibits Transcription of the MicroRNA Cluster MC-let-7a-1∼let-7d via Noncanonical E-box

Wang

Lin

et al. 2011

Journal of Biological Chemistry

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Background:The three microRNAs from miRNA cluster MC-let-7a-1ϳlet-7d are often down-regulated in human cancers. Results: We functionally characterized the promoter and investigated the transcriptional regulation of MC-let-7a-1ϳlet-7d. Conclusion: MYC oncoprotein could inhibit the transcription of MC-let-7a-1ϳlet-7d via binding to a noncanonical E-box. Significance: Understanding how MC-let-7a-1ϳlet-7d is regulated could shed light on identifying new molecular targets and designing novel treatment for cancers.

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Julia Jun Li

MYC Protein Inhibits Transcription of the MicroRNA Cluster MC-let-7a-1∼let-7d via Noncanonical E-box

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