Space ight entails a variety of environmental and psychological stressors that may have long-term physiological and genomic consequences. Metabolomics, an approach that investigates the terminal metabolites of complex physiological alterations, takes into account the dynamic state of the human body and allows the identi cation and quanti cation of down-stream metabolic outputs linked to upstream physiological and genomic regulation by stress. Employing a metabolomics-based approach, this study investigated the longitudinal metabolic perturbations of male (n=40) and female (n=11) astronauts on 4-6-month missions to the International Space Station. Proton nuclear magnetic resonance ( 1 H-NMR) spectroscopy followed by univariate, multivariate and machine learning analyses were used on blood serum to examine sex-speci c metabolic changes at various time points throughout the astronauts' missions, and the metabolic effects of long-duration space travel. Space travel generated sex-speci c changes in energy metabolism, bone mineral and muscle regulation, immunity, and macromolecule maintenance and synthesis. Additionally, metabolic signatures suggest differential metabolic responses especially during the recovery period, with females requiring more time to adjust to return to Earth. These ndings provide insight into the perturbations in glucose and amino acid metabolism and macromolecule biosynthesis that result from the stressors of long-duration space ight. Metabolomic biomarkers may provide a viable approach to predicting and diagnosing health risks associated with prolonged space travel and other physiological challenges on Earth.
Spaceflight entails a variety of environmental and psychological stressors that may have long-term physiological and genomic consequences. Metabolomics, an approach that investigates the terminal metabolites of complex physiological alterations, takes into account the dynamic state of the human body and allows the identification and quantification of down-stream metabolic outputs linked to up-stream physiological and genomic regulation by stress. Employing a metabolomics-based approach, this study investigated the longitudinal metabolic perturbations of male (n=40) and female (n=11) astronauts on 4-6-month missions to the International Space Station. Proton nuclear magnetic resonance (1H-NMR) spectroscopy followed by univariate, multivariate and machine learning analyses were used on blood serum to examine sex-specific metabolic changes at various time points throughout the astronauts’ missions, and the metabolic effects of long-duration space travel. Space travel generated sex-specific changes in energy metabolism, bone mineral and muscle regulation, immunity, and macromolecule maintenance and synthesis. Additionally, metabolic signatures suggest differential metabolic responses especially during the recovery period, with females requiring more time to adjust to return to Earth. These findings provide insight into the perturbations in glucose and amino acid metabolism and macromolecule biosynthesis that result from the stressors of long-duration spaceflight. Metabolomic biomarkers may provide a viable approach to predicting and diagnosing health risks associated with prolonged space travel and other physiological challenges on Earth.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.