Tumor necrosis factor-alpha (TNF-alpha) is a central mediator of the immune response to pathogens, but may also exert neurotoxic effects, thereby contributing to immunopathology. To define the role of TNF during the course of brain abscess, TNF-deficient (TNF(0/0) mice were stereotaxically infected with Staphylococcus (S.) aureus-laden agarose beads. In comparison to 100% survival of wild type (WT) mice, TNF(0/0) mice displayed high mortality rates (54%) in the initial phase of abscess development as well as significantly increased morbidity in the course of the disease. The worse clinical outcome was due to an increased intracerebral (i.c.) bacterial load in TNF(0/0) mice as compared to WT mice. The impaired control of S. aureus was associated with reduced inductible nitric oxide synthase (iNOS) mRNA and protein expression in TNF(0/0)mice. Similarly, numbers of inflammatory leukocytes, cytokine expression of IL-6, IL-12p40, IFNgamma IL-beta mRNA, and brain edema were significantly increased in TNF(0/0)mice as compared to WT animals. In addition, resolution of i.c. infiltrates was delayed in TNF(0/0)mice correlating with reduced apoptosis of inflammatory leukocytes and formation of a fibrous abscess capsule. Collectively, these data demonstrate that TNF is of key importance for the control of S. aureus-induced brain abscess and regulates the ensuing host immune response.
PurposeFor police officers, the ability to distinguish between truthful and deceptive statements in interrogations is essential. However, research shows that their classification accuracy is typically rather low. The purpose of this paper is to investigate the ability to detect deception as a function of perceived experience, in a sample of German police officers and police trainees.Design/methodology/approachThe authors had the participants judge ten video recordings of a mock crime with respect to the displayed suspects’ truthfulness. Following the assumptions and findings of previous research, the authors expected their manipulation of perceived experience to increase detection accuracy, but expected objective experience not to be correlated with the ability to detect deception.FindingsAs expected, police officers and trainees in the experience condition achieved higher accuracy than control participants. On the objective self‐report measures of experience, no relationship with classification accuracy was found.Practical implicationsThe findings suggest that police officers’ objective experience does not perfectly translate into subjective experience. A subjective feeling of experience can be sufficient enough to increase detection accuracy, even if one is objectively inexperienced.Originality/valueThe manipulation proved to be a simple and efficient method of increasing judgmental accuracy in lie detection without increasing police officers’ actual knowledge or changing their beliefs about deception cues.
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